Hypofractionated Accelerated Radiotherapy for Head and Neck Cancer in Fragile Patients

IF 2.2 3区医学 Q1 OTORHINOLARYNGOLOGY Head and Neck-Journal for the Sciences and Specialties of the Head and Neck Pub Date : 2024-11-22 DOI:10.1002/hed.27989

Segado-Guillot Salvador, García-Anaya María Jesús, Toledo-Serrano María Dolores, Calvo-Tudela Ángel, Prieto-Granados Patricia, Torres-Tabanera María Dolores, Medina-Carmona José Antonio, Gómez-Millán Jaime

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Abstract

Background

Radiotherapy combined with chemotherapy is the treatment of choice for locally advanced non-metastatic head and neck cancer. Elderly and frail patients cannot always tolerate this therapy and no clear guidelines exist for their treatment. This retrospective study aims to analyze the efficacy and safety of hypofractionated radiotherapy for these patients.

Methods

A retrospective analysis of 65 patients treated with hypofractionated radiotherapy, using a regimen of 57.5 Gy in 23 fractions of 2.5 Gy.

Results

Most patients completed the prescribed treatment. Overall survival at 2 and 5 years was 55% and 33%. Locoregional control at 2 and 5 years was 76% and 51%, respectively. Performance status was an independent prognostic factor (p = 0.05).

Conclusions

This radiotherapy schedule was well tolerated, showing a high rate of locoregional control and shortening the overall treatment time. Prospective studies are necessary to establish the most effective treatment for frail patients.

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针对脆弱患者的头颈部癌症低分次加速放疗。

背景：放疗联合化疗是局部晚期非转移性头颈癌的首选治疗方法。年老体弱的患者往往无法耐受这种疗法，目前也没有明确的治疗指南。这项回顾性研究旨在分析低分次放疗对这些患者的疗效和安全性：方法：对65名接受过低分次放射治疗的患者进行回顾性分析，治疗方案为57.5 Gy，23次分次，每次2.5 Gy：大多数患者完成了规定的治疗。2年和5年的总生存率分别为55%和33%。2年和5年的局部控制率分别为76%和51%。表现状态是一个独立的预后因素（P = 0.05）：该放疗方案耐受性良好，局部控制率高，缩短了总体治疗时间。有必要进行前瞻性研究，以确定对体弱患者最有效的治疗方法。

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来源期刊

Head and Neck-Journal for the Sciences and Specialties of the Head and Neck 医学-耳鼻喉科学

CiteScore

7.00

自引率

6.90%

发文量

278

审稿时长

1.6 months

期刊介绍： Head & Neck is an international multidisciplinary publication of original contributions concerning the diagnosis and management of diseases of the head and neck. This area involves the overlapping interests and expertise of several surgical and medical specialties, including general surgery, neurosurgery, otolaryngology, plastic surgery, oral surgery, dermatology, ophthalmology, pathology, radiotherapy, medical oncology, and the corresponding basic sciences.

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