Melatonin as an adjunctive therapy in cardiovascular disease management.

IF 2.6 4区综合性期刊 Q2 MULTIDISCIPLINARY SCIENCES Science Progress Pub Date : 2024-10-01 DOI:10.1177/00368504241299993

Zan Luo, Yuan Yuan Tang, Liang Zhou

{"title":"Melatonin as an adjunctive therapy in cardiovascular disease management.","authors":"Zan Luo, Yuan Yuan Tang, Liang Zhou","doi":"10.1177/00368504241299993","DOIUrl":null,"url":null,"abstract":"<p><p>Melatonin, N-acetyl-5-methoxytryptamine, is a neuroendocrine hormone secreted by the pineal gland. This pleiotropic indoleamine possesses amphiphilic properties, allowing it to penetrate most biological barriers and exert its effects at the subcellular level. Importantly, melatonin also plays a crucial role in regulating the body's response to circadian rhythms, adapting to internal and external environmental cues. Melatonin functions as a powerful antioxidant and free radical scavenger, protecting cells from oxidative damage. Its diverse physiological roles include maintaining the functional integrity of endothelial cells, thereby preventing atherosclerosis, a major contributor to cardiovascular disease. Additionally, melatonin exhibits antioxidant and free radical scavenging properties, potentially improving metabolic disorders. These combined effects suggest a unique adjunctive therapeutic potential for melatonin in treating cardiovascular diseases. This review aims to explore the mechanisms by which melatonin interacts with the cardiovascular system and investigates its potential use as an adjunctive therapeutic agent in managing cardiovascular disease.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"107 4","pages":"368504241299993"},"PeriodicalIF":2.6000,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Science Progress","FirstCategoryId":"103","ListUrlMain":"https://doi.org/10.1177/00368504241299993","RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MULTIDISCIPLINARY SCIENCES","Score":null,"Total":0}

引用次数: 0

Abstract

Melatonin, N-acetyl-5-methoxytryptamine, is a neuroendocrine hormone secreted by the pineal gland. This pleiotropic indoleamine possesses amphiphilic properties, allowing it to penetrate most biological barriers and exert its effects at the subcellular level. Importantly, melatonin also plays a crucial role in regulating the body's response to circadian rhythms, adapting to internal and external environmental cues. Melatonin functions as a powerful antioxidant and free radical scavenger, protecting cells from oxidative damage. Its diverse physiological roles include maintaining the functional integrity of endothelial cells, thereby preventing atherosclerosis, a major contributor to cardiovascular disease. Additionally, melatonin exhibits antioxidant and free radical scavenging properties, potentially improving metabolic disorders. These combined effects suggest a unique adjunctive therapeutic potential for melatonin in treating cardiovascular diseases. This review aims to explore the mechanisms by which melatonin interacts with the cardiovascular system and investigates its potential use as an adjunctive therapeutic agent in managing cardiovascular disease.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

褪黑素作为心血管疾病治疗的辅助疗法。

褪黑素，即 N-乙酰基-5-甲氧基色胺，是松果体分泌的一种神经内分泌激素。这种多效吲哚胺具有两亲性，能够穿透大多数生物屏障，在亚细胞水平发挥效应。重要的是，褪黑激素还在调节人体对昼夜节律的反应、适应内外环境线索方面发挥着至关重要的作用。褪黑激素是一种强大的抗氧化剂和自由基清除剂，可保护细胞免受氧化损伤。褪黑素的生理作用多种多样，包括维持内皮细胞功能的完整性，从而防止动脉粥样硬化这一心血管疾病的主要诱因。此外，褪黑素还具有抗氧化和清除自由基的特性，可改善代谢紊乱。这些综合效应表明，褪黑素在治疗心血管疾病方面具有独特的辅助治疗潜力。本综述旨在探讨褪黑素与心血管系统相互作用的机制，并研究其作为辅助治疗剂用于治疗心血管疾病的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Science Progress Multidisciplinary-Multidisciplinary

CiteScore

3.80

自引率

0.00%

发文量

119

期刊介绍： Science Progress has for over 100 years been a highly regarded review publication in science, technology and medicine. Its objective is to excite the readers'' interest in areas with which they may not be fully familiar but which could facilitate their interest, or even activity, in a cognate field.