Transcriptomic and epigenomic profiling reveals altered responses to diesel emissions in Alzheimer's disease both in vitro and in population-based data

IF 13 1区 医学 Q1 CLINICAL NEUROLOGY Alzheimer's & Dementia Pub Date : 2024-11-23 DOI:10.1002/alz.14347
Liudmila Saveleva, Tereza Cervena, Claudia Mengoni, Michal Sima, Zdenek Krejcik, Kristyna Vrbova, Jitka Sikorova, Laura Mussalo, Tosca O. E. de Crom, Zuzana Šímová, Mariia Ivanova, Muhammad Ali Shahbaz, Elina Penttilä, Heikki Löppönen, Anne M. Koivisto, M. Arfan Ikram, Pasi I Jalava, Tarja Malm, Sweelin Chew, Michal Vojtisek-Lom, Jan Topinka, Rosalba Giugno, Pavel Rössner, Katja M. Kanninen
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Abstract

Studies have correlated living close to major roads with Alzheimer's disease (AD) risk. However, the mechanisms responsible for this link remain unclear.

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转录组学和表观基因组学分析揭示了阿尔茨海默氏症患者在体外和人群数据中对柴油排放物反应的改变
研究表明,居住地靠近主干道与阿尔茨海默病(AD)风险相关。然而,造成这种联系的机制仍不清楚。
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来源期刊
Alzheimer's & Dementia
Alzheimer's & Dementia 医学-临床神经学
CiteScore
14.50
自引率
5.00%
发文量
299
审稿时长
3 months
期刊介绍: Alzheimer's & Dementia is a peer-reviewed journal that aims to bridge knowledge gaps in dementia research by covering the entire spectrum, from basic science to clinical trials to social and behavioral investigations. It provides a platform for rapid communication of new findings and ideas, optimal translation of research into practical applications, increasing knowledge across diverse disciplines for early detection, diagnosis, and intervention, and identifying promising new research directions. In July 2008, Alzheimer's & Dementia was accepted for indexing by MEDLINE, recognizing its scientific merit and contribution to Alzheimer's research.
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