The role of the immune system in Parkinson's disease pathogenesis: A focus on Th17 cells - A systematic review and meta-analysis

IF 2.9 4区医学 Q3 IMMUNOLOGY Journal of neuroimmunology Pub Date : 2024-11-17 DOI:10.1016/j.jneuroim.2024.578484

Zihan Jiang , Honghao Huang , Yiqun Chen , Haobo Xie , Yangguang Lu , Yaoyin Ge , Ruotong Yao , Lingsheng Wang , Zihao Wu , Yiran Bu , Guangyong Chen , Dehao Yang

{"title":"The role of the immune system in Parkinson's disease pathogenesis: A focus on Th17 cells - A systematic review and meta-analysis","authors":"Zihan Jiang , Honghao Huang , Yiqun Chen , Haobo Xie , Yangguang Lu , Yaoyin Ge , Ruotong Yao , Lingsheng Wang , Zihao Wu , Yiran Bu , Guangyong Chen , Dehao Yang","doi":"10.1016/j.jneuroim.2024.578484","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div>Parkinson's disease (PD) has been linked to T helper 17 (Th17) cells in prior investigations, but the evidence remains inconclusive. To gain a deeper understanding of this potential connection, we conducted a systematic review and meta-analysis.</div></div><div><h3>Methods</h3><div>A comprehensive search for relevant studies published up to July 8, 2023, was performed across PubMed, EMBASE, and Cochrane Library databases. A random-effect model was employed to synthesize effect sizes and their corresponding 95 % confidence intervals (CIs). Leave-one-out sensitivity analysis and funnel plots with trim-and-fill were utilized to assess the combined results' robustness.</div></div><div><h3>Results</h3><div>Thirteen studies were ultimately included in the meta-analysis. Pooled effect sizes indicated a significantly higher percentage of Th17 cells in PD patients (Standardized Mean Difference [SMD] = 1.00, 95 % CI 0.30–1.71). Notably, Th17 cell levels were more elevated in Asian PD patients (SMD = 1.33, 95 % CI 0.31–2.35). Additionally, the percentage of Th17 cells positively correlated with Movement Disorder Society Unified Parkinson's Disease Rating Scale-III (UPDRS-III) scores (<em>r</em> = 0.22, 95 % CI 0.01–0.41), indicating a link to motor dysfunction. Conversely, a negative correlation was observed with Cognitive function scale scores (<em>r</em> = − 0.27, 95 % CI -0.47–-0.04), suggesting a potential association with cognitive decline.</div></div><div><h3>Conclusions</h3><div>This study revealed a positive association between Th17 cells and PD, with PD patients exhibiting elevated Th17 levels. Furthermore, the percentage of Th17 cells correlated with motor and cognitive impairments in PD patients.</div></div>","PeriodicalId":16671,"journal":{"name":"Journal of neuroimmunology","volume":"398 ","pages":"Article 578484"},"PeriodicalIF":2.9000,"publicationDate":"2024-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of neuroimmunology","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0165572824002030","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"IMMUNOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Background

Parkinson's disease (PD) has been linked to T helper 17 (Th17) cells in prior investigations, but the evidence remains inconclusive. To gain a deeper understanding of this potential connection, we conducted a systematic review and meta-analysis.

Methods

A comprehensive search for relevant studies published up to July 8, 2023, was performed across PubMed, EMBASE, and Cochrane Library databases. A random-effect model was employed to synthesize effect sizes and their corresponding 95 % confidence intervals (CIs). Leave-one-out sensitivity analysis and funnel plots with trim-and-fill were utilized to assess the combined results' robustness.

Results

Thirteen studies were ultimately included in the meta-analysis. Pooled effect sizes indicated a significantly higher percentage of Th17 cells in PD patients (Standardized Mean Difference [SMD] = 1.00, 95 % CI 0.30–1.71). Notably, Th17 cell levels were more elevated in Asian PD patients (SMD = 1.33, 95 % CI 0.31–2.35). Additionally, the percentage of Th17 cells positively correlated with Movement Disorder Society Unified Parkinson's Disease Rating Scale-III (UPDRS-III) scores (r = 0.22, 95 % CI 0.01–0.41), indicating a link to motor dysfunction. Conversely, a negative correlation was observed with Cognitive function scale scores (r = − 0.27, 95 % CI -0.47–-0.04), suggesting a potential association with cognitive decline.

Conclusions

This study revealed a positive association between Th17 cells and PD, with PD patients exhibiting elevated Th17 levels. Furthermore, the percentage of Th17 cells correlated with motor and cognitive impairments in PD patients.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

免疫系统在帕金森病发病机制中的作用：聚焦Th17细胞--系统综述与荟萃分析。

背景：先前的研究发现帕金森病（PD）与T辅助细胞17（Th17）有关，但证据仍不确定。为了深入了解这种潜在的联系，我们进行了一项系统回顾和荟萃分析：方法：我们在 PubMed、EMBASE 和 Cochrane Library 数据库中全面检索了截至 2023 年 7 月 8 日发表的相关研究。采用随机效应模型合成效应大小及其相应的 95% 置信区间 (CI)。为了评估综合结果的稳健性，采用了留空敏感性分析和带有修剪填充功能的漏斗图：荟萃分析最终纳入了 13 项研究。汇总效应大小表明，PD 患者的 Th17 细胞比例明显更高（标准化均值差 [SMD] = 1.00，95 % CI 0.30-1.71）。值得注意的是，亚裔帕金森病患者的 Th17 细胞水平更高（SMD = 1.33，95 % CI 0.31-2.35）。此外，Th17细胞的百分比与运动障碍协会统一帕金森病量表-III（UPDRS-III）评分呈正相关（r = 0.22，95 % CI 0.01-0.41），表明与运动功能障碍有关。相反，与认知功能量表评分呈负相关（r = - 0.27，95 % CI -0.47--0.04），表明可能与认知功能下降有关：本研究揭示了Th17细胞与帕金森病之间的正相关，帕金森病患者的Th17细胞水平升高。此外，Th17细胞的百分比与帕金森病患者的运动和认知障碍相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Journal of neuroimmunology 医学-免疫学

CiteScore

6.10

自引率

3.00%

发文量

154

审稿时长

37 days

期刊介绍： The Journal of Neuroimmunology affords a forum for the publication of works applying immunologic methodology to the furtherance of the neurological sciences. Studies on all branches of the neurosciences, particularly fundamental and applied neurobiology, neurology, neuropathology, neurochemistry, neurovirology, neuroendocrinology, neuromuscular research, neuropharmacology and psychology, which involve either immunologic methodology (e.g. immunocytochemistry) or fundamental immunology (e.g. antibody and lymphocyte assays), are considered for publication.