Early and late postnatal lung distribution of collagen type VI in preterm and term infants

IF 1.9 4区 医学 Q3 PHYSIOLOGY Respiratory Physiology & Neurobiology Pub Date : 2024-11-21 DOI:10.1016/j.resp.2024.104366
Laszlo Markasz , Hamid Mobini-Far , Richard Sindelar
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Abstract

Collagen type VI (COL6) is an important component of the extracellular matrix (EM) and may have a major role in lung development and disease. Studies on COL6 expression during lung development are mainly based on animal models. The aim of the study was to define COL6 expression pattern in lung parenchyma in infants with different lung maturational stages.
COL6 expression in 115 lung samples from deceased newborn infants (21–41 weeks’ gestational age; 0–228 days’ postnatal age) was studied by immunohistochemistry combined with digital image analysis.
The distribution of COL6 expression was generally heterogeneous in the lung parenchyma of preterm and term infants. The size of the high-density and low-density areas appeared with logarithmic correlation and COL6 defined the basement membrane (BM) with a prominent expression around the air spaces in the canalicular stage during the first postnatal week. Infants at the alveolar stage showed linear correlation and a fine filamentous appearance during the first week of postnatal life, similarly to adults.
COL6 is condensed to areas corresponding to the BM during the first postnatal week of the canalicular stage of lung development. After the first postnatal week COL6 expression changes to a microfibrillar appearance in the ECM, similar to the pattern that characterizes the later alveolar stage and adults. The localization of COL6 during the canalicular and saccular stages might have a higher impact on lung development than the amount of COL6.
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早产儿和足月儿出生后早期和晚期肺部 VI 型胶原蛋白的分布。
六型胶原(COL6)是细胞外基质(EM)的重要组成部分,可能在肺部发育和疾病中起着重要作用。有关肺发育过程中 COL6 表达的研究主要基于动物模型。本研究旨在确定不同肺成熟阶段婴儿肺实质中 COL6 的表达模式。通过免疫组化结合数字图像分析,研究了115例死亡新生儿(胎龄21-41周;出生后0-228天)肺部样本中COL6的表达情况。在早产儿和足月儿的肺实质中,COL6的表达分布总体上是不均匀的。高密度区和低密度区的大小呈对数相关,COL6定义了基底膜(BM),在出生后第一周的管腔期,COL6在气室周围有显著表达。处于肺泡期的婴儿与成人相似,在出生后第一周表现出线性相关和细丝状外观。在肺管发育阶段的出生后第一周,COL6 浓缩到与 BM 相对应的区域。出生后第一周后,COL6 的表达在 ECM 中转变为微纤维状,与肺泡后期和成人的模式相似。在管状期和囊状期,COL6 的定位可能比 COL6 的数量对肺发育的影响更大。
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来源期刊
CiteScore
4.80
自引率
8.70%
发文量
104
审稿时长
54 days
期刊介绍: Respiratory Physiology & Neurobiology (RESPNB) publishes original articles and invited reviews concerning physiology and pathophysiology of respiration in its broadest sense. Although a special focus is on topics in neurobiology, high quality papers in respiratory molecular and cellular biology are also welcome, as are high-quality papers in traditional areas, such as: -Mechanics of breathing- Gas exchange and acid-base balance- Respiration at rest and exercise- Respiration in unusual conditions, like high or low pressure or changes of temperature, low ambient oxygen- Embryonic and adult respiration- Comparative respiratory physiology. Papers on clinical aspects, original methods, as well as theoretical papers are also considered as long as they foster the understanding of respiratory physiology and pathophysiology.
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