A comparison of cycloplegic effect of cyclopentolate 0.5% versus 1.0% eye drops with five different refraction measurement modalities in young adults.

Klemens Paul Kaiser, Christoph Lwowski, Faisal Nazir, Thomas Kohnen, Yaroslava Wenner
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Abstract

Purpose: To compare the refraction before and after cycloplegia with 0.5% and 1.0% cyclopentolate eye drops using five different measurement modalities.

Methods: This prospective, clinical comparative study enrolled 96 eyes of 48 healthy patients with a mean age of 26.6 ± 4.21 years (range: 19-34). Subjective refraction, retinoscopy, and objective refraction were measured using three autorefractometers: Topcon KR-800 (TC), Retinomax K-plus 3 (RM + 3), and Retinomax K-plus Screeen (RM + S) under noncycloplegic and cycloplegic conditions. Cycloplegia was performed in the right eye using 0.5% and in the left eye with 1.0% cyclopentolate eye drops. Differences in refraction in noncycloplegia and cycloplegia, between cycloplegia with 0.5% and 1.0% cyclopentolate, and between the devices were investigated.

Results: Cycloplegic mean spherical equivalent was -1.77 ± 2.34 diopters (D) (-9.75 to + 1.625). All approaches showed a statistically significant hyperopic shift (p < 0.001, each) after induction of cycloplegia using both regimes. Lowest median (interquartile range) hyperopic shift was shown by TC (0.25 D (0.38)) and retinoscopy (0.25D (0.75)), and the highest by RM + 3 (0.75 (1.31)). No statistically significant differences between cycloplegia using 0.5% and 1.0% regimens were shown in all modalities (p > 0.05, each). In noncycloplegia, there were greater differences compared to cycloplegia. No influence of iris color on the refraction was found.

Conclusion: After induction of cycloplegia all devices showed a hyperopic shift and good comparability to retinoscopy. In all measurement modalities, no significant refraction differences between 0.5% and 1.0% cyclopentolate eye drops were seen. Therefore, 0.5% cyclopentolate was proven to have a sufficient effect with presumably better tolerability.

Key messages: What is known Cycloplegic refraction is a key test in the evaluation of any patient with active accommodation. The most frequently used clinical tests to determine the exact refraction are retinoscopy, subjective refraction, and objective refraction using autorefractometry. What is new No significant differences in the refraction between cycloplegia using 0.5% and 1.0% cyclopentolate eye drops were found. In noncycloplegia, hand-held autorefractometers tend to measure higher myopia. The evaluation of cycloplegic refraction showed good comparability between retinoscopy and subjective refraction as well as three different autorefractometers.

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环戊丙酸 0.5%与 1.0%滴眼液与五种不同屈光度测量方法对青少年屈光效果的比较。
目的:使用五种不同的测量方法,比较滴用 0.5% 和 1.0% 环戊托品滴眼液前后的屈光度:这项前瞻性临床比较研究共纳入了 48 名健康患者的 96 只眼睛,他们的平均年龄为 26.6 ± 4.21 岁(19-34 岁)。使用三种自动屈光仪测量主观屈光度、视网膜镜和客观屈光度:Topcon KR-800 (TC)、Retinomax K-plus 3 (RM + 3) 和 Retinomax K-plus Screeen (RM + S)。右眼使用 0.5% 环戊丙酸滴眼液,左眼使用 1.0% 环戊丙酸滴眼液。研究了非环形屈光手术和环形屈光手术中屈光度的差异、环形屈光手术中使用 0.5%和 1.0%环戊托品屈光度的差异以及不同设备间屈光度的差异:环形屈光手术的平均球面等效度数为-1.77 ± 2.34屈光度(D)(-9.75 至 + 1.625)。所有方法都显示出显著的远视偏移(P 0.05,每种方法)。在非环形屈光手术中,与环形屈光手术相比差异更大。虹膜颜色对屈光度没有影响:结论:在诱导环形麻痹后,所有设备都显示出远视偏移,并与视网膜镜具有良好的可比性。在所有测量模式中,0.5% 和 1.0% 环戊托品滴眼液的屈光度均无明显差异。因此,0.5% 环戊丙酸滴眼液被证明具有足够的疗效,而且可能具有更好的耐受性:已知信息 环戊托品滴眼液屈光度数是评估任何活动性住宿患者的关键测试。确定准确屈光度最常用的临床测试是视网膜镜检查、主观屈光度检查和使用自动屈光度计的客观屈光度检查。新发现 使用 0.5% 和 1.0% 环戊托品滴眼液进行环戊托品验光时,屈光度没有明显差异。在非环形屈光检查中,手持式自动屈光仪往往会测量出更高的近视度数。对环视屈光度的评估表明,视网膜镜和主观屈光度以及三种不同的自动屈光仪之间具有良好的可比性。
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来源期刊
CiteScore
5.40
自引率
7.40%
发文量
398
审稿时长
3 months
期刊介绍: Graefe''s Archive for Clinical and Experimental Ophthalmology is a distinguished international journal that presents original clinical reports and clini-cally relevant experimental studies. Founded in 1854 by Albrecht von Graefe to serve as a source of useful clinical information and a stimulus for discussion, the journal has published articles by leading ophthalmologists and vision research scientists for more than a century. With peer review by an international Editorial Board and prompt English-language publication, Graefe''s Archive provides rapid dissemination of clinical and clinically related experimental information.
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