Causal association between serum 25-hydroxyvitamin D levels and gestational diabetes mellitus: a bidirectional two-sample Mendelian randomization study.

IF 3 3区医学 Q2 ENDOCRINOLOGY & METABOLISM Endocrine Pub Date : 2024-11-23 DOI:10.1007/s12020-024-04100-y

Wei Li, Kaili Zhu, Zhongqiang Ma, Tao Wang

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Abstract

Purpose: Previous investigations have assessed the connection between vitamin D deficiency and an increased risk of gestational diabetes mellitus (GDM); however, the findings remain inconsistent. The purpose of this study was to investigate the causal relationship between 25-hydroxyvitamin D (25OHD) levels and GDM.

Methods: Summary statistics data from genome-wide association studies (GWASs) were used to perform a bidirectional two-sample Mendelian randomization (MR) study. A total of 417,580 Europeans from the UK Biobank provided summary statistics data for 25OHD. The tenth data release of the FinnGen study provided the data for GDM, comprising 14,718 cases and 215,592 controls. For the univariate MR (uvMR) investigations, we employed the inverse variance weighted (IVW) method as our major analytical approach. Multiple sensitivity analyses were performed to evaluate the robustness of the results. Moreover, multivariate MR (mvMR) studies were conducted to account for potential confounding variables, including obesity, insulin resistance, and lipid traits.

Results: In the forward MR study, uvMR analysis did not provide evidence supporting a causal effect of 25OHD levels on the risk of GDM [IVW odds ratio (OR): 1.07, 95% confidence interval (CI): 0.95 to 1.19, p = 0.273]. After adjusting for obesity, fasting insulin levels, and lipid traits, the findings from the mvMR analysis aligned with those of the uvMR analysis. In the reverse MR study, uvMR analysis indicated that GDM had no causal effect on serum 25OHD levels (IVW β = -0.003, p = 0.804), and the robustness of this finding was confirmed in the mvMR study.

Conclusion: Our MR research revealed no causal effect of serum 25OHD levels on GDM, suggesting that 25OHD deficiency does not correlate with an increased risk of GDM. Furthermore, our reverse analysis revealed no causal effect of GDM on 25OHD levels.

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血清 25- 羟维生素 D 水平与妊娠糖尿病之间的因果关系：双向双样本孟德尔随机研究。

目的：以往的研究评估了维生素 D 缺乏与妊娠糖尿病（GDM）风险增加之间的关系，但研究结果仍不一致。本研究旨在探讨 25- 羟基维生素 D（25OHD）水平与妊娠糖尿病之间的因果关系：方法：利用全基因组关联研究（GWAS）的汇总统计数据进行双向双样本孟德尔随机化（MR）研究。英国生物库（UK Biobank）共为 417,580 名欧洲人提供了 25OHD 的汇总统计数据。FinnGen研究的第十次数据发布提供了GDM的数据，包括14718个病例和215592个对照。在单变量磁共振（uvMR）调查中，我们采用了反方差加权法（IVW）作为主要分析方法。我们进行了多重敏感性分析，以评估结果的稳健性。此外，我们还进行了多变量磁共振（mvMR）研究，以考虑潜在的混杂变量，包括肥胖、胰岛素抵抗和脂质特征：在前瞻性 MR 研究中，uvMR 分析未提供证据支持 25OHD 水平对 GDM 风险的因果效应[IVW 比值比 (OR)：1.07，95% 置信区间 (CI)：0.95 至 1.19，p = 0.273]。对肥胖、空腹胰岛素水平和血脂特征进行调整后，mvMR 分析结果与 uvMR 分析结果一致。在反向 MR 研究中，uvMR 分析表明 GDM 对血清 25OHD 水平没有因果效应（IVW β = -0.003，p = 0.804），这一结果的稳健性在 mvMR 研究中得到了证实：我们的磁共振研究显示，血清 25OHD 水平对 GDM 没有因果效应，这表明 25OHD 缺乏与 GDM 风险的增加无关。此外，我们的反向分析表明，GDM 与 25OHD 水平没有因果关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Endocrine ENDOCRINOLOGY & METABOLISM-

CiteScore

6.50

自引率

5.40%

发文量

295

审稿时长

1.5 months

期刊介绍： Well-established as a major journal in today’s rapidly advancing experimental and clinical research areas, Endocrine publishes original articles devoted to basic (including molecular, cellular and physiological studies), translational and clinical research in all the different fields of endocrinology and metabolism. Articles will be accepted based on peer-reviews, priority, and editorial decision. Invited reviews, mini-reviews and viewpoints on relevant pathophysiological and clinical topics, as well as Editorials on articles appearing in the Journal, are published. Unsolicited Editorials will be evaluated by the editorial team. Outcomes of scientific meetings, as well as guidelines and position statements, may be submitted. The Journal also considers special feature articles in the field of endocrine genetics and epigenetics, as well as articles devoted to novel methods and techniques in endocrinology. Endocrine covers controversial, clinical endocrine issues. Meta-analyses on endocrine and metabolic topics are also accepted. Descriptions of single clinical cases and/or small patients studies are not published unless of exceptional interest. However, reports of novel imaging studies and endocrine side effects in single patients may be considered. Research letters and letters to the editor related or unrelated to recently published articles can be submitted. Endocrine covers leading topics in endocrinology such as neuroendocrinology, pituitary and hypothalamic peptides, thyroid physiological and clinical aspects, bone and mineral metabolism and osteoporosis, obesity, lipid and energy metabolism and food intake control, insulin, Type 1 and Type 2 diabetes, hormones of male and female reproduction, adrenal diseases pediatric and geriatric endocrinology, endocrine hypertension and endocrine oncology.