Frailty and the Survival Outcomes of Patients With Laryngeal Squamous Cell Cancer.

IF 2.3 3区医学 Q1 OTORHINOLARYNGOLOGY Head and Neck-Journal for the Sciences and Specialties of the Head and Neck Pub Date : 2024-11-22 DOI:10.1002/hed.27951

Cameron McCann, Rhona Hurley, Josh McGovern, Katrina Knight, Nicholas J W Rattray, Catriona M Douglas

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Abstract

Background: Frailty increases the risk of mortality in the head and neck cancer population. This study examines the association between frailty and survival outcomes in patients with laryngeal squamous cell cancer (LSCC).

Method: Retrospective data collection from patients in the West of Scotland diagnosed with LSCC between 2014 and 2020. The Modified Five Item Frailty Index (mFI-5) measures frailty and categorizes patients according to their level of frailty. Statistical tests used were the Mann-Whitney U-test or ANOVA for differences in means and survival analyses for overall survival time.

Results: There were 867 patients included. Seventy-eight percent (n = 676) of patients were deemed frail. Median survival for "not frail" patients was 78 months and "severely frail" was 23 months. The palliative treatment group had worse overall survival outcomes compared to curative (hazard ratio (HR) of 7.96, p < 0.001).

Conclusion: This study demonstrates frailty is common in patients with LSCC and leads to worse mortality and survival outcomes.

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虚弱与喉鳞状细胞癌患者的生存结果

背景：虚弱会增加头颈部癌症患者的死亡风险。本研究探讨了喉鳞状细胞癌（LSCC）患者体弱与生存结果之间的关系：方法：对2014年至2020年期间苏格兰西部确诊为喉鳞状细胞癌的患者进行回顾性数据收集。改良五项虚弱指数（mFI-5）测量虚弱程度，并根据虚弱程度对患者进行分类。统计检验采用曼-惠特尼U检验或方差分析来检验平均值的差异，并对总生存时间进行生存分析：结果：共纳入 867 名患者。78%的患者（n = 676）被认为体弱。不虚弱 "患者的中位生存期为 78 个月，"严重虚弱 "患者的中位生存期为 23 个月。与治愈性治疗相比，姑息治疗组的总生存期更短（危险比（HR）为 7.96，P 结论：这项研究表明，体弱在 LSCC 患者中很常见，会导致死亡率和生存率降低。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Head and Neck-Journal for the Sciences and Specialties of the Head and Neck 医学-耳鼻喉科学

CiteScore

7.00

自引率

6.90%

发文量

278

审稿时长

1.6 months

期刊介绍： Head & Neck is an international multidisciplinary publication of original contributions concerning the diagnosis and management of diseases of the head and neck. This area involves the overlapping interests and expertise of several surgical and medical specialties, including general surgery, neurosurgery, otolaryngology, plastic surgery, oral surgery, dermatology, ophthalmology, pathology, radiotherapy, medical oncology, and the corresponding basic sciences.