Association between multiple metals exposure and metabolic dysfunction-associated fatty liver disease among Chinese adults

IF 3.6 3区 医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Journal of Trace Elements in Medicine and Biology Pub Date : 2024-11-17 DOI:10.1016/j.jtemb.2024.127566
Qing Liu , Jianing Bi , Gaojie Fan , Mingyang Wu , Xiya Qin , Qing Fang , Surong Mei , Zhengce Wan , Yongman Lv , Lulu Song , Youjie Wang
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Abstract

Background

Previous research has investigated the hepatotoxicity of single metal exposure. However, there is limited evidence about metal mixture and their association with metabolic dysfunction-associated fatty liver disease (MAFLD), particularly in the Chinese population.

Objective

To investigate the individual and combine effects of 20 metals on MAFLD in a large population in China.

Methods

This study included 3651 participants from the Medical Physical Examination Center of Tongji Hospital, Wuhan, China. MAFLD was identified based on ultrasonic graphic evidence of hepatic steatosis and the presence of overweight/obese, diabetes mellitus, or metabolic dysregulation. Inductively coupled plasma mass spectrometry (ICP-MS) was used to determine urinary concentrations of 20 metals. Logistic regression was used to assess the relationship between individual metal and MAFLD, with results presented as odds ratios (ORs) and 95 % confidence intervals (CIs). Weighted quantile sum (WQS) regression was performed to evaluate the combine effect of metals.

Results

The prevalence of MAFLD among the participants was 32.1 % (1173/3651). In singe-metal analysis, high exposure to zinc (OR =1.42; 95 % CI = 1.27, 1.59) and selenium (OR = 1.23; 95 % CI = 1.10, 1.39) were positively associated with MAFLD. No significant association was found for other metals. WQS regression analysis showed that urinary metal mixture was positively associated with MAFLD (OR = 1.32, 95 % CI: 1.15, 1.51), with zinc (50.4 %) being the largest contributor, followed by barium (10.8 %).

Conclusions

In conclusion, our finding suggested that exposure to the mixture of metals was positively correlated with MAFLD, with zinc being the major contributor.
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中国成年人接触多种金属与代谢功能障碍相关脂肪肝之间的关系
背景:以往的研究对单一金属暴露的肝毒性进行了调查。然而,关于金属混合物及其与代谢功能障碍相关性脂肪肝(MAFLD)的关系,特别是在中国人群中,证据还很有限:调查中国大量人群中 20 种金属对代谢功能障碍相关性脂肪肝的个体和综合影响:本研究纳入了中国武汉同济医院体检中心的 3651 名体检者。MAFLD是根据肝脏脂肪变性的超声图谱证据以及是否存在超重/肥胖、糖尿病或代谢失调来确定的。采用电感耦合等离子体质谱法(ICP-MS)测定尿液中 20 种金属的浓度。采用逻辑回归评估单个金属与 MAFLD 之间的关系,结果以几率比(OR)和 95 % 置信区间(CI)表示。加权量子和(WQS)回归用于评估金属的综合效应:结果:参与者的 MAFLD 患病率为 32.1%(1173/3651)。在单金属分析中,锌(OR = 1.42; 95 % CI = 1.27, 1.59)和硒(OR = 1.23; 95 % CI = 1.10, 1.39)的高暴露量与 MAFLD 呈正相关。其他金属则无明显关联。WQS回归分析表明,尿液中的金属混合物与MAFLD呈正相关(OR = 1.32,95 % CI:1.15,1.51),其中锌(50.4 %)的贡献最大,其次是钡(10.8 %):总之,我们的研究结果表明,接触金属混合物与 MAFLD 呈正相关,锌是主要的致病因素。
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来源期刊
CiteScore
6.60
自引率
2.90%
发文量
202
审稿时长
85 days
期刊介绍: The journal provides the reader with a thorough description of theoretical and applied aspects of trace elements in medicine and biology and is devoted to the advancement of scientific knowledge about trace elements and trace element species. Trace elements play essential roles in the maintenance of physiological processes. During the last decades there has been a great deal of scientific investigation about the function and binding of trace elements. The Journal of Trace Elements in Medicine and Biology focuses on the description and dissemination of scientific results concerning the role of trace elements with respect to their mode of action in health and disease and nutritional importance. Progress in the knowledge of the biological role of trace elements depends, however, on advances in trace elements chemistry. Thus the Journal of Trace Elements in Medicine and Biology will include only those papers that base their results on proven analytical methods. Also, we only publish those articles in which the quality assurance regarding the execution of experiments and achievement of results is guaranteed.
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