Exploring the potential of dental calculus to shed light on past human migrations in Oceania

IF 14.7 1区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES Nature Communications Pub Date : 2024-11-24 DOI:10.1038/s41467-024-53920-z

Irina M. Velsko, Zandra Fagernäs, Monica Tromp, Stuart Bedford, Hallie R. Buckley, Geoffrey Clark, John Dudgeon, James Flexner, Jean-Christophe Galipaud, Rebecca Kinaston, Cecil M. Lewis, Elizabeth Matisoo-Smith, Kathrin Nägele, Andrew T. Ozga, Cosimo Posth, Adam B. Rohrlach, Richard Shing, Truman Simanjuntak, Matthew Spriggs, Anatauarii Tamarii, Frédérique Valentin, Edson Willie, Christina Warinner

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Abstract

The Pacific islands and Island Southeast Asia have experienced multiple waves of human migrations, providing a case study for exploring the potential of ancient microbiomes to study human migration. We perform a metagenomic study of archaeological dental calculus from 102 individuals, originating from 10 Pacific islands and 1 island in Island Southeast Asia spanning ~3000 years. Oral microbiome DNA preservation in calculus is far higher than that of human DNA in archaeological bone, and comparable to that of calculus from temperate regions. Oral microbial community composition is minimally driven by time period and geography in Pacific and Island Southeast Asia calculus, but is found to be distinctive compared to calculus from Europe, Africa, and Asia. Phylogenies of individual bacterial species in Pacific and Island Southeast Asia calculus reflect geography. Archaeological dental calculus shows good preservation in tropical regions and the potential to yield information about past human migrations, complementing studies of the human genome.

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探索牙结石揭示大洋洲过去人类迁徙的潜力

太平洋岛屿和东南亚岛屿经历了多次人类迁徙浪潮，为探索古代微生物组研究人类迁徙的潜力提供了一个案例。我们对来自 10 个太平洋岛屿和 1 个东南亚岛屿的 102 人的考古牙结石进行了元基因组研究，时间跨度约为 3000 年。牙结石中保存的口腔微生物组 DNA 远高于考古骨骼中的人类 DNA，与温带地区牙结石中的保存率相当。在太平洋和东南亚岛屿的牙结石中，口腔微生物群落组成受时间段和地理位置的影响很小，但与欧洲、非洲和亚洲的牙结石相比，其口腔微生物群落组成具有独特性。太平洋和东南亚岛国牙结石中单个细菌物种的系统发育反映了地理环境。考古牙结石在热带地区保存完好，有可能提供有关过去人类迁徙的信息，对人类基因组研究起到补充作用。

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来源期刊

Nature Communications Biological Science Disciplines-

CiteScore

24.90

自引率

2.40%

发文量

6928

审稿时长

3.7 months

期刊介绍： Nature Communications, an open-access journal, publishes high-quality research spanning all areas of the natural sciences. Papers featured in the journal showcase significant advances relevant to specialists in each respective field. With a 2-year impact factor of 16.6 (2022) and a median time of 8 days from submission to the first editorial decision, Nature Communications is committed to rapid dissemination of research findings. As a multidisciplinary journal, it welcomes contributions from biological, health, physical, chemical, Earth, social, mathematical, applied, and engineering sciences, aiming to highlight important breakthroughs within each domain.