The use of GnRH analogues in combination with exogenous gonadotropins in infertile women.

Acta endocrinologica. Supplementum Pub Date : 1988-01-01
R Fleming, M E Jamieson, M P Hamilton, W P Black, M C Macnaughton, J R Coutts
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Abstract

GnRH analogues suppress LH fluctuations and produce a condition of hypogonadotropic hypogonadism. This action combined with treatment with human menopausal gonadotropins (hMG) has been exploited in programmes of induction of follicular growth in infertile women for both in vivo and in vitro fertilisation. There is improved clinical control over the process of ovulation and the phenomenon of premature luteinization in women with polycystic ovary disease has been eliminated.

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GnRH类似物与外源性促性腺激素在不孕妇女中的联合应用。
GnRH类似物抑制LH波动,产生促性腺激素功能低下。这种作用与人类绝经期促性腺激素(hMG)治疗相结合,已被用于诱导不孕妇女的卵泡生长,用于体内和体外受精。临床对排卵过程的控制得到了改善,多囊卵巢疾病妇女的黄体早生现象已被消除。
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Gonadotropins. Meeting to mark the retirement of Professor Wilfrid Butt. Stratford-upon Avon. 18th September. What are we measuring in gonadotropin assays? Gonadotropins--domestic animals. Pulsatile GnRH therapy for the induction of ovulation in hypogonadotropic hypogonadism. Precocious and delayed sexual development in children.
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