Hasan Sari, Yakup Alsancak, Ahmet Seyfeddin Gurbuz, Oznur Keskin, Sefa Tatar, Mehmet Akif Duzenli
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引用次数: 0
Abstract
Introduction: It is now known that the microbiota is far beyond the microbial communities living in certain parts of our body and functions like a metabolic organ. In addition, the microbiota, through its metabolites, is involved in the pathophysiology or progression of a wide range of diseases, from atherosclerotic diseases to metabolic diseases and even neurological diseases. Among these metabolites, trimethylamine n-oxide metabolite has been shown to be particularly effective in atherosclerotic heart diseases.
Materials and Methods: A total of 155 patients, who underwent coroner angiography for stable angina were included in the study. Of these patients, 81 patients with coronary artery ectasia (patient group) and 74 patients without coronary artery ectasia (control group) were evaluated for trimethylamine n-oxide metabolite.
Results: Statistically significantly higher trimethylamine n-oxide metabolite levels were observed in the coronary artery ectasia group compared to the control group.
Conclusion: The significantly higher trimethylamine n-oxide levels in patients with coronary artery ectasia without coronary artery disease suggest that the microbiota and its metabolites independently play a role in the pathophysiology or progression of vascular remodeling or endothelial dysfunctions. Also, its effect on the endothelial surface may depend on the threshold value.
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