The activin-follistatin system: Key regulator of kidney development, regeneration, inflammation, and fibrosis.

IF 9.3 2区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Cytokine & Growth Factor Reviews Pub Date : 2024-11-19 DOI:10.1016/j.cytogfr.2024.11.004

Izumi Nagayama, Yoshinori Takei, Shunsuke Takahashi, Mari Okada, Akito Maeshima

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Abstract

Activins, multifunctional cytokines of the transforming growth factor-beta superfamily, play critical roles in the regulation of growth and differentiation in multiple biological systems. Activin activity is finely regulated by the endogenous antagonist follistatin. Early studies reported that activins are involved in renal organogenesis, but subsequent research demonstrated that activins also play a significant role in kidney regeneration following injury. The results of more recent studies suggest activins play roles in both inflammatory kidney diseases and renal fibrosis, conditions that often culminate in end-stage renal disease. Given these findings, the inhibition of activin activity represents a promising therapeutic approach for treating a range of kidney disorders. This review discusses the latest discoveries concerning the role of the activin-follistatin system in renal development and pathophysiology and explores the potential therapeutic implications of targeting this system in the management of kidney diseases.

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激活素-软骨素系统：肾脏发育、再生、炎症和纤维化的关键调节因子

活性蛋白是转化生长因子-β超家族的多功能细胞因子，在多个生物系统的生长和分化调节中发挥着关键作用。活化素的活性受内源性拮抗剂软骨素的精细调节。早期研究报告称，活化素参与了肾脏器官的生成，但随后的研究表明，活化素在损伤后的肾脏再生中也发挥着重要作用。最近的研究结果表明，激活蛋白在炎症性肾脏疾病和肾脏纤维化中都起着作用，而这些疾病往往最终导致终末期肾病。鉴于这些发现，抑制激活蛋白的活性是治疗一系列肾脏疾病的一种很有前景的治疗方法。这篇综述讨论了有关激活素-软骨素系统在肾脏发育和病理生理学中作用的最新发现，并探讨了针对这一系统治疗肾脏疾病的潜在治疗意义。

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来源期刊

Cytokine & Growth Factor Reviews 生物-生化与分子生物学

CiteScore

21.10

自引率

1.50%

发文量

审稿时长

22 days

期刊介绍： Cytokine & Growth Factor Reviews is a leading publication that focuses on the dynamic fields of growth factor and cytokine research. Our journal offers a platform for authors to disseminate thought-provoking articles such as critical reviews, state-of-the-art reviews, letters to the editor, and meeting reviews. We aim to cover important breakthroughs in these rapidly evolving areas, providing valuable insights into the multidisciplinary significance of cytokines and growth factors. Our journal spans various domains including signal transduction, cell growth and differentiation, embryonic development, immunology, tumorigenesis, and clinical medicine. By publishing cutting-edge research and analysis, we aim to influence the way researchers and experts perceive and understand growth factors and cytokines. We encourage novel expressions of ideas and innovative approaches to organizing content, fostering a stimulating environment for knowledge exchange and scientific advancement.