M A Darenskaya, A A Semendyaev, D A Stupin, S I Kolesnikov, N V Semenova, D V Tukhieva, A V Shcherbatykh, L I Kolesnikova
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引用次数: 0
Abstract
The tissue preparations of the pelvic veins obtained during laparoscopy were examined. The expression of markers of proliferation (Ki-67), apoptosis (p53), and angiogenesis (CD31, CD34), as well as estrogen and progesterone receptors in women with pelvic varicose veins was assessed by the immunohistochemical method. A decrease in the median expression of the proliferation marker (Ki-67) and estrogen and progesterone receptors and simultaneous increase in the expression of apoptosis marker (p53) and activation of angiogenesis processes (markers CD31 and CD34) were observed with increasing the severity of the disease. These data extend our understanding of the pathogenetic mechanisms of pelvic varicose veins and contribute to the development of methods of pathogenetically based targeted therapy.
期刊介绍：
Bulletin of Experimental Biology and Medicine presents original peer reviewed research papers and brief reports on priority new research results in physiology, biochemistry, biophysics, pharmacology, immunology, microbiology, genetics, oncology, etc. Novel trends in science are covered in new sections of the journal - Biogerontology and Human Ecology - that first appeared in 2005.
World scientific interest in stem cells prompted inclusion into Bulletin of Experimental Biology and Medicine a quarterly scientific journal Cell Technologies in Biology and Medicine (a new Russian Academy of Medical Sciences publication since 2005). It publishes only original papers from the leading research institutions on molecular biology of stem and progenitor cells, stem cell as the basis of gene therapy, molecular language of cell-to-cell communication, cytokines, chemokines, growth and other factors, pilot projects on clinical use of stem and progenitor cells.
The Russian Volume Year is published in English from April.
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