A Case of B-Cell Lymphoblastic Lymphoma Presenting with an Isolated Epidural Mass Treated Successfully with Radiotherapy Followed by United Kingdom Acute Lymphoblastic Leukemia (UKALL) Chemotherapy Protocol.

IF 1.1 Q4 HEMATOLOGY Hematology Reports Pub Date : 2024-11-23 DOI:10.3390/hematolrep16040069
Musa Fares Alzahrani
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引用次数: 0

Abstract

Background: B-cell lymphoblastic lymphoma (B-LBL) is an aggressive type of non-Hodgkin lymphoma that usually involves lymph nodes, skin and soft tissue. Bone marrow and peripheral blood are normally spared from involvement in the disease. B-LBL typically forms solid masses that have similar pathologic and immunophenotypic features to their liquid counterpart, B-cell acute lymphoblastic leukemia (B-ALL). The presentation of B-LBL with a solitary epidural mass at the cervical spine is very rare and the optimal treatment of such cases is unknown. Most of the literature on the management of B-LBL comes from small case series, pediatric patients, or as part of retrospective data that combine B-LBL with B-ALL cases.

Case presentation: The case presented herein is a unique presentation that was treated using three modalities, namely surgical resection, radiotherapy and consolidation with systemic chemotherapy, adopted from the United Kingdom acute lymphoblastic leukemia (UKALL14) protocol.

Conclusions: The patient attained complete remission following the planned treatment and is still in remission for more than four and half years from the time of his initial diagnosis.

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英国急性淋巴细胞白血病 (UKALL) 化疗方案成功治疗了一例出现孤立硬膜外肿块的 B 细胞淋巴细胞淋巴瘤患者。
背景:B细胞淋巴母细胞淋巴瘤(B-LBL)是一种侵袭性非霍奇金淋巴瘤,通常累及淋巴结、皮肤和软组织。骨髓和外周血通常不会受累。B-LBL通常形成实体肿块,其病理和免疫分型特征与液态的B细胞急性淋巴细胞白血病(B-ALL)相似。B-LBL伴有颈椎硬膜外单发肿块的病例非常罕见,此类病例的最佳治疗方法尚不清楚。有关B-LBL治疗的大部分文献来自小型病例系列、儿科患者,或将B-LBL与B-ALL病例合并的回顾性资料:本文介绍的病例是一个独特的病例,采用了英国急性淋巴细胞白血病(UKALL14)方案中的三种治疗方式,即手术切除、放疗和全身化疗巩固治疗:结论:患者在接受计划的治疗后获得了完全缓解,从最初确诊到现在已超过四年半。
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来源期刊
Hematology Reports
Hematology Reports HEMATOLOGY-
CiteScore
0.90
自引率
0.00%
发文量
47
审稿时长
10 weeks
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