Platelet-Rich Fibrin (PRF) Analyzed for Cytokine Profiles - A Misguided Hope for Osteogenesis in Jawbone Defects? Research and Clinical Observational Study.

IF 1.8 Q3 DENTISTRY, ORAL SURGERY & MEDICINE Clinical, Cosmetic and Investigational Dentistry Pub Date : 2024-11-19 eCollection Date: 2024-01-01 DOI:10.2147/CCIDE.S488206

Johann Lechner, Volker vonBaehr, Cornelia Doebis, Florian Notter, Fabian Schick

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Abstract

Background: Platelet-rich fibrin (PRF) blood concentrates are used in oral implantology and defect surgery to promote osteoneogenesis in Bone Marrow Defects in Jawbone (BMDJ), according to the morphology of fatty-degenerative osteonecrosis also called FDOJ.

Question: Can the benefit of PRF on alveolar osteoneogenesis be confirmed by cytokine analysis?.

Methods: The cytokine expressions of the PRF samples in 26 patients undergoing BMDJ/FDOJ surgery in the same session were analysed for seven cytokines (RANTES/CCL5; FGF-2; IL-1RA; Il-6; IL-8; MCP-1; TNF-a) by multiplex (Luminex). The FDOJ samples of these 26 BMDJ/FDOJ patients were analysed for the RANTES/CCL5 expression only.

Results: Cytokine expression in PRF is compared to reference values for healthy medullary bone of the jaw and BMDJ/FDOJ and shows that the cytokine expressions of the PRF samples do not compensate or counteract prima vista for the cytokine dysregulations present in the BMDJ/FDOJ areas.

Discussion: To define the aid of cytokines studied in PRF in the restoration of the immunological dysregulation in areas of BMDJ/FDOJ, literature is reviewed comparing RANTES/CCL5, IL-1ra, TNF-α and MCP-1/CCL2 expression in PRF and BMDJ/FDOJ. Immunoregulatory properties of PRF in alveolar bone restoration are evaluated.

Summary: PRF was mistakenly thought to be a cure for bone healing, which is here shown to be incorrect. Enoral Ultrasound Sonography of bone density is available for the clinical measurement of individually developed osteoneogenesis by PRF.

Conclusion: The multiplex analysis of PRF shows a dynamic and cytokine-based interaction with osteoneogenesis that is not yet fully clarified.

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富血小板纤维蛋白（PRF）细胞因子谱分析--被误导的颌骨缺损成骨希望？研究与临床观察性研究。

背景：富血小板纤维蛋白（PRF）血液浓缩物可用于口腔种植和缺损手术，根据脂肪变性骨坏死（又称FDOJ）的形态，促进颌骨骨髓缺损（BMDJ）的骨生成：方法：通过细胞因子分析确认PRF对牙槽骨骨生成的益处：方法：采用多重方法（Luminex）分析了在同一疗程中接受BMDJ/FDOJ手术的26例患者的PRF样本中7种细胞因子（RANTES/CCL5；FGF-2；IL-1RA；Il-6；IL-8；MCP-1；TNF-a）的表达情况。对这26名BMDJ/FDOJ患者的FDOJ样本仅分析了RANTES/CCL5的表达：结果：将 PRF 中细胞因子的表达与健康颌骨髓质和 BMDJ/FDOJ 的参考值进行比较，结果显示 PRF 样本中细胞因子的表达并不能初步补偿或抵消 BMDJ/FDOJ 区域存在的细胞因子失调：为了确定在 PRF 中研究的细胞因子对恢复 BMDJ/FDOJ 区域免疫失调的帮助，我们回顾了比较 PRF 和 BMDJ/FDOJ 中 RANTES/CCL5、IL-1ra、TNF-α 和 MCP-1/CCL2 表达的文献。评估了 PRF 在牙槽骨修复中的免疫调节特性。摘要：PRF 曾被误认为是治疗骨愈合的良药，但事实证明这是不正确的。口内超声骨密度声学造影可用于临床测量 PRF 单独形成的骨生成：对PRF的多重分析表明，细胞因子与骨生成之间存在动态的相互作用，而这种相互作用尚未完全阐明。

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