Investigating Clinical Factors Influencing Pulmonary Fibrosis in Acute Diquat Poisoning.

IF 2.1 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL International Journal of General Medicine Pub Date : 2024-11-20 eCollection Date: 2024-01-01 DOI:10.2147/IJGM.S488317
Meili Xu, Hongliu Chen, Jianjing Chen, Rongzong Ye, Huan Xiao, Jingwen Li, Chaoqian Li
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Abstract

Objective: This study aimed to explore the factors influencing pulmonary fibrosis in patients with acute diquat poisoning through logistic regression analysis.

Methods: A retrospective analysis was conducted on 68 cases of acute diquat poisoning due to suicidal intent admitted to our hospital from February 2020 to March 2023. Patients were divided into a combined group (28 cases with pulmonary fibrosis) and an acute diquat poisoning group (40 cases without). A healthy control group consisted of 40 individuals. General data were compared among the three groups, and laboratory indicators were analyzed. Single and multiple logistic regression analyses were performed to identify risk factors for pulmonary fibrosis.

Results: There were no significant differences in gender, age, BMI, poisoning status, or treatment timing among the groups (P > 0.05). The combined group had significantly higher diquat ingestion dose, SIRS score, SOFA score, and APACHE II score compared to the poisoning group (P < 0.05). In the acute poisoning group, these scores were also higher than in the healthy controls (P < 0.05). Laboratory indicators, including Hb, PLT, ALP, DBil, ALB, BUN, Glu, BNP, and pH, showed no significant differences (P > 0.05). However, WBC, ALT, TBil, DBil, Cr, K+, Tn I, and Lac levels were significantly higher in the combined group compared to the acute poisoning group (P < 0.05). Logistic regression analysis identified factors influencing pulmonary fibrosis as diquat ingestion dose, K+, ALT, PaO2, Lac, and HCO3-.

Conclusion: The factors influencing pulmonary fibrosis in acute diquat poisoning include diquat ingestion dose, K+, ALT, PaO2, Lac, and HCO3-. These findings enhance understanding of pulmonary fibrosis pathogenesis and may inform clinical management for affected patients.

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调查影响急性敌草快中毒肺纤维化的临床因素
目的:本研究旨在通过逻辑回归分析探讨影响急性敌草快中毒患者肺纤维化的因素:本研究旨在通过Logistic回归分析探讨影响急性敌草快中毒患者肺纤维化的因素:对我院 2020 年 2 月至 2023 年 3 月收治的 68 例因自杀而急性敌草快中毒的患者进行回顾性分析。患者被分为合并组(28 例合并肺纤维化)和急性敌草快中毒组(40 例未合并肺纤维化)。健康对照组由 40 人组成。对三组患者的一般数据进行比较,并对实验室指标进行分析。为确定肺纤维化的风险因素,进行了单次和多次逻辑回归分析:结果:各组在性别、年龄、体重指数、中毒状况和治疗时间上无明显差异(P>0.05)。与中毒组相比,联合组的敌草快摄入剂量、SIRS评分、SOFA评分和APACHE II评分均明显高于中毒组(P < 0.05)。急性中毒组的这些评分也高于健康对照组(P < 0.05)。实验室指标,包括 Hb、PLT、ALP、DBil、ALB、BUN、Glu、BNP 和 pH,均无显著差异(P > 0.05)。然而,与急性中毒组相比,合并组的白细胞、谷丙转氨酶、TBil、DBil、Cr、K+、Tn I 和 Lac 水平明显更高(P < 0.05)。逻辑回归分析确定了影响肺纤维化的因素为敌草快摄入剂量、K+、ALT、PaO2、Lac和HCO3-:结论:影响急性敌草快中毒肺纤维化的因素包括敌草快摄入剂量、K+、ALT、PaO2、Lac和HCO3-。这些发现加深了人们对肺纤维化发病机制的理解,并可为临床治疗受影响的患者提供参考。
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来源期刊
International Journal of General Medicine
International Journal of General Medicine Medicine-General Medicine
自引率
0.00%
发文量
1113
审稿时长
16 weeks
期刊介绍: The International Journal of General Medicine is an international, peer-reviewed, open access journal that focuses on general and internal medicine, pathogenesis, epidemiology, diagnosis, monitoring and treatment protocols. The journal is characterized by the rapid reporting of reviews, original research and clinical studies across all disease areas. A key focus of the journal is the elucidation of disease processes and management protocols resulting in improved outcomes for the patient. Patient perspectives such as satisfaction, quality of life, health literacy and communication and their role in developing new healthcare programs and optimizing clinical outcomes are major areas of interest for the journal. As of 1st April 2019, the International Journal of General Medicine will no longer consider meta-analyses for publication.
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