The Role of Nt-Pro-Bnp in Predicting Outcome in Pediatric Hypertrophic Cardiomyopathy.

IF 1.5 4区医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS Pediatric Cardiology Pub Date : 2024-11-24 DOI:10.1007/s00246-024-03702-7

Nicoletta Cantarutti, Rachele Adorisio, Sara Di Marzio, Marianna Cicenia, Irma Battipaglia, Erica Mencarelli, Massimo Stefano Silvetti, Antonio Amodeo, Fabrizio Drago

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Abstract

Hypothesis: The aim of the study was to evaluate the correlation between NTproBNP and left ventricular mass (LVM) in children affected by hypertrophic cardiomyopathy (HCM), both asymptomatic, symptomatic, and with implantable cardioverter-defibrillator (ICD).

Methods: A total of 225 pediatric patients were evaluated and 45 were enrolled in the study because met inclusion criteria (age < 18 years; diagnosis of hypertrophic cardiomyopathy; NTproBNP > 600 pg/ml).

Results: The analysis showed a significant correlation between NTproBNP level and LVM (p = 0.024). ANOVA test showed that high level of NTproBNP and LVM were significantly correlated to ICD implantation (p = 0.001; p = 0.003). Multivariate analysis showed NTproBNP as an independent risk factor for ICD implantation (p = 0.035).

Conclusion: Our study showed that NTproBNP levels directly correlated to LVM and disease progression and it was found to be predictive, together with LVM, of ICD implantation.

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Nt-Pro-Bnp 在预测小儿肥厚型心肌病预后中的作用。

假设：该研究旨在评估肥厚型心肌病（HCM）患儿（包括无症状、有症状和使用植入式心律转复除颤器（ICD）的患儿）NTproBNP与左心室质量（LVM）之间的相关性：方法：共对 225 名儿童患者进行了评估，其中 45 名患者符合纳入标准（年龄 600 pg/ml）：结果：分析显示 NTproBNP 水平与 LVM 之间存在明显相关性（p = 0.024）。方差分析检验显示，高水平的 NTproBNP 和 LVM 与 ICD 植入显著相关（p = 0.001；p = 0.003）。多变量分析显示，NTproBNP是ICD植入的独立危险因素（p = 0.035）：我们的研究表明，NTproBNP 水平与 LVM 和疾病进展直接相关，而且它与 LVM 一起被认为是 ICD 植入的预测因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pediatric Cardiology 医学-小儿科

CiteScore

3.30

自引率

6.20%

发文量

258

审稿时长

12 months

期刊介绍： The editor of Pediatric Cardiology welcomes original manuscripts concerning all aspects of heart disease in infants, children, and adolescents, including embryology and anatomy, physiology and pharmacology, biochemistry, pathology, genetics, radiology, clinical aspects, investigative cardiology, electrophysiology and echocardiography, and cardiac surgery. Articles which may include original articles, review articles, letters to the editor etc., must be written in English and must be submitted solely to Pediatric Cardiology.