Thioctic acid shield against lipopolysaccharide depression and endoplasmic reticulum stress: GR7M/Homer/ATF6 signaling.

IF 2.4 Q3 MEDICINE, RESEARCH & EXPERIMENTAL Future Science OA Pub Date : 2024-12-31 Epub Date: 2024-11-25 DOI:10.1080/20565623.2024.2422791

Mai O Kadry, Rehab M Abdel-Megeed

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Abstract

Aim: Endoplasmic reticulum stress triggers neuronal unfolded protein accumulation, contributing to the pathophysiology of depression psychiatric illnesses.Materials & methods: The brain-derived neurotrophic factor (BDNF), metabotropic glutamate receptor type 7 (GRM7), phosphoinisitol kinase-3 (PIK3), serine/threonine kinase 1 (AKT) and Homer1 may afford an important signaling pathways in LPS induced depression rat model. Herein, thioctic acid, Burdock and propolis therapeutic index on lipopolysaccharide (LPS)-induced depression was monitored. BDNF/PI3K/GR7M/ATF6/CHOP/XBP/AKT/Homer-1 signaling pathways also opened a novel avenue in the integration of synaptic neurotransmission.Results: The aforementioned treatments elevated GR7M/BDNF/GABA gene expression meanwhile decreased reactive oxygen species generation (Malondialdehyde/glutathione reductase/Total antioxidant capacity) and reduced the expression of ATF6/CHOP/PI3K/AKT/XBP/Homer-1 post LPS elevation.Conclusion: Thioctic acid, propolis and Burdock are prospective therapeutic agents via GRM7/BDNF/AKT/PI3K/ATF6/XBP/homer -1 signaling pathways in LPS-induced depression.

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硫辛酸可抵御脂多糖抑制和内质网应激：GR7M/Homer/ATF6信号传导。

目的：内质网应激引发神经元未折叠蛋白积累，导致抑郁症精神疾病的病理生理学：脑源性神经营养因子（BDNF）、代谢型谷氨酸受体7型（GRM7）、磷脂酰肌醇激酶3（PIK3）、丝氨酸/苏氨酸激酶1（AKT）和Homer1可能是LPS诱导抑郁症大鼠模型的重要信号通路。在此，研究人员监测了硫辛酸、牛蒡和蜂胶对脂多糖（LPS）诱导的抑郁症的治疗指数。BDNF/PI3K/GR7M/ATF6/CHOP/XBP/AKT/Homer-1信号通路也为整合突触神经传递开辟了一条新途径：结果：上述处理提高了GR7M/BDNF/GABA基因的表达，同时减少了活性氧的生成（丙二醛/谷胱甘肽还原酶/总抗氧化能力），并降低了LPS升高后ATF6/CHOP/PI3K/AKT/XBP/Homer-1的表达：结论：硫辛酸、蜂胶和牛蒡可通过GRM7/BDNF/AKT/PI3K/ATF6/XBP/homer-1信号通路对LPS诱导的抑郁症进行治疗。

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来源期刊

Future Science OA MEDICINE, RESEARCH & EXPERIMENTAL-

CiteScore

5.00

自引率

4.00%

发文量

审稿时长

13 weeks

期刊介绍： Future Science OA is an online, open access, peer-reviewed title from the Future Science Group. The journal covers research and discussion related to advances in biotechnology, medicine and health. The journal embraces the importance of publishing all good-quality research with the potential to further the progress of research in these fields. All original research articles will be considered that are within the journal''s scope, and have been conducted with scientific rigour and research integrity. The journal also features review articles, editorials and perspectives, providing readers with a leading source of commentary and analysis. Submissions of the following article types will be considered: -Research articles -Preliminary communications -Short communications -Methodologies -Trial design articles -Trial results (including early-phase and negative studies) -Reviews -Perspectives -Commentaries