Coexistence of somatic and psychological symptoms of depression among community-dwelling older adults is associated with the incidence of dementia.

IF 3.4 3区 医学 Q2 NEUROSCIENCES Journal of Alzheimer's Disease Pub Date : 2025-01-01 Epub Date: 2024-11-25 DOI:10.1177/13872877241299118
Yuka Misu, Kota Tsutsumimoto, Yuto Kiuchi, Kazuhei Nishimoto, Tomoka Ohata, Hiroyuki Shimada
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Abstract

Background: Depression in old age is associated with the incidence of dementia. However, whether a combination of somatic and psychological symptoms influences the risk of dementia has not been fully investigated.

Objective: We aimed to determine the association between the combination of psychological and somatic symptoms of depression and the incidence of dementia.

Methods: This prospective cohort study included 2111 community-dwelling older adults (median age = 73 years, interquartile range = 68-78 years, 39.5% male). Participants were evaluated for 5 years from baseline to assess the incidence of dementia. Somatic symptoms were defined as the presence of one or more symptoms of fatigue, weight loss, sleep disturbances, and abnormal appetite. Psychological symptoms were assessed using the 15-item Geriatric Depression Scale. Participants were stratified into four groups based on the presence or absence of somatic and psychological symptoms. A Cox proportional hazards model was used to examine the associations with the incidence of dementia, adjusted for potential confounders.

Results: The hazard ratios for the incidence of dementia in the somatic (HR 1.42, 95% CI: 0.96-2.09) and psychological symptoms-only groups (HR 1.47, 95% CI: 0.83-2.59) were not significantly different; however, they were significantly higher in the coexistent group than in the normal group (HR 1.91, 95% CI: 1.24-2.94).

Conclusions: The coexistence of somatic and psychological symptoms of depression increases the risk of dementia. Therefore, interventions should consider both somatic and psychological symptoms to prevent or delay dementia.

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居住在社区的老年人同时出现躯体和心理抑郁症状与痴呆症的发病率有关。
背景:老年抑郁症与痴呆症的发病率有关。然而,躯体症状和心理症状的结合是否会影响痴呆症的发病风险尚未得到充分研究:我们旨在确定抑郁症的心理和躯体症状组合与痴呆症发病率之间的关系:这项前瞻性队列研究纳入了 2111 名居住在社区的老年人(中位年龄 = 73 岁,四分位数间距 = 68-78 岁,39.5% 为男性)。从基线开始对参与者进行为期 5 年的评估,以评估痴呆症的发病率。躯体症状是指出现一种或多种疲劳、体重减轻、睡眠障碍和食欲异常症状。心理症状采用 15 项老年抑郁量表进行评估。根据是否存在躯体和心理症状,将参与者分为四组。在对潜在的混杂因素进行调整后,采用考克斯比例危险模型来研究与痴呆症发病率的关系:结果:躯体症状组(HR 1.42,95% CI:0.96-2.09)和仅有心理症状组(HR 1.47,95% CI:0.83-2.59)痴呆症发病率的危险比没有显著差异;但并存组的痴呆症发病率明显高于正常组(HR 1.91,95% CI:1.24-2.94):结论:抑郁症的躯体症状和心理症状并存会增加痴呆症的风险。因此,干预措施应同时考虑躯体症状和心理症状,以预防或延缓痴呆症的发生。
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来源期刊
Journal of Alzheimer's Disease
Journal of Alzheimer's Disease 医学-神经科学
CiteScore
6.40
自引率
7.50%
发文量
1327
审稿时长
2 months
期刊介绍: The Journal of Alzheimer''s Disease (JAD) is an international multidisciplinary journal to facilitate progress in understanding the etiology, pathogenesis, epidemiology, genetics, behavior, treatment and psychology of Alzheimer''s disease. The journal publishes research reports, reviews, short communications, hypotheses, ethics reviews, book reviews, and letters-to-the-editor. The journal is dedicated to providing an open forum for original research that will expedite our fundamental understanding of Alzheimer''s disease.
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