Spontaneous regression of head and neck squamous cell carcinoma: a systematic review and meta-analysis of case reports.

IF 1.1 4区医学 Q3 OTORHINOLARYNGOLOGY Journal of Laryngology and Otology Pub Date : 2024-11-01 Epub Date: 2024-11-25 DOI:10.1017/S0022215124001336

Kin Lun Lau, Zarius Ferozepurwalla

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Abstract

Objective: A systematic review of case reports in spontaneous regression of head and neck squamous cell carcinoma (SCC) was carried out to investigate the pattern and characteristics of this phenomenon.

Methods: A systematic search of case studies of spontaneously regressed head and neck SCC was carried out in Ovid Embase, Ovid Medline and Pubmed. Methodological quality was assessed by ascertainment of diagnosis and overall details of reports. Outcomes included patient demographics, head and neck SCC characteristics and clinical course of disease.

Results: A total of 8 cases were included and 50 per cent (n = 4) of the reported cases were SCC of the vocal folds. All cases received a surgical biopsy and three cases had possible febrile episodes preceding regression. The mean length of time to regression was 4.3 months.

Discussion: Spontaneous regression in head and neck SCC is likely to be under-reported. A better understanding of how the host immune system can instigate an antitumour response will shed light on the development of novel treatments.

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头颈部鳞状细胞癌的自发消退：病例报告的系统回顾和荟萃分析。

目的对头颈部鳞状细胞癌（SCC）自发消退的病例报告进行系统回顾，以研究这种现象的模式和特点：在 Ovid Embase、Ovid Medline 和 Pubmed 上对自发消退的头颈部鳞状细胞癌病例研究进行了系统检索。通过确定诊断和报告的整体细节来评估方法学质量。研究结果包括患者的人口统计学特征、头颈部 SCC 特征和临床病程：结果：共收录了 8 例病例，50%（n = 4）的报告病例为声带 SCC。所有病例均接受了手术活检，其中三例病例在消退前可能出现过发热。病例消退的平均时间为 4.3 个月：讨论：头颈部SCC的自发性消退可能未得到充分报道。更好地了解宿主免疫系统如何激发抗肿瘤反应将有助于开发新的治疗方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Laryngology and Otology 医学-耳鼻喉科学

CiteScore

3.20

自引率

11.80%

发文量

593

审稿时长

3-6 weeks

期刊介绍： The Journal of Laryngology & Otology (JLO) is a leading, monthly journal containing original scientific articles and clinical records in otology, rhinology, laryngology and related specialties. Founded in 1887, JLO is absorbing reading for ENT specialists and trainees. The journal has an international outlook with contributions from around the world, relevant to all specialists in this area regardless of the country in which they practise. JLO contains main articles (original, review and historical), case reports and short reports as well as radiology, pathology or oncology in focus, a selection of abstracts, book reviews, letters to the editor, general notes and calendar, operative surgery techniques, and occasional supplements. It is fully illustrated and has become a definitive reference source in this fast-moving subject area. Published monthly an annual subscription is excellent value for money. Included in the subscription is access to the JLO interactive web site with searchable abstract database of the journal archive back to 1887.