Synthesis and applications of luminescent metal organic frameworks (MOFs) for sensing dipicolinic acid in biological and water samples: a review

Abstract

The detection of trace quantities of 2,6-dipicolinic acid (DPA) in real-world samples is crucial for early disease diagnosis and routine health monitoring. Metal–organic frameworks (MOFs), recognized for their diverse structural architectures, have emerged as advanced multifunctional hybrid materials. One of the most notable properties of MOFs is their luminescence (L), which can arise from structural ligands, guest molecules, and emissive metal ions. Luminescent MOFs have shown significant promise as platforms for sensor design. This review highlights the application of luminescent MOFs in the detection of DPA in biological and aqueous environments. It provides a comprehensive discussion of the various detection strategies employed in luminescent MOF-based DPA sensors. Additionally, it explores the origins of L in MOFs, their synthesis, and the mechanisms underlying their sensing capabilities. The article also addresses key challenges and limitations in this field, offering practical insights for the development of efficient luminescent MOFs for DPA detection.