The efficacy of InterRhythmic care for depression: A randomized control trial.

IF 3.7 2区医学 Q1 PSYCHIATRY Journal of psychiatric research Pub Date : 2024-11-20 DOI:10.1016/j.jpsychires.2024.11.028

Chuchen Xu, Yanhong Geng, Xiaohe Fan, Zheyi Wei, Weichieh Yang, Fan Wang, Yiming Chen, Bin Xie, Wu Hong

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Abstract

Objective: This study investigates the efficacy of an InterRhythmic Care (IRC) for major depressive disorder (MDD). There is a lack of clinical studies on its effect on depression.

Methods: In this eight-week, randomized, single-blind, controlled trial, 120 patients with MDD were randomly assigned to receive IRC or Internet general psychoeducation (IGP). Participants' depressive and anxiety symptoms, interpersonal relationships, social function, and biological rhythms were assessed using the 17-item Hamilton Depression Rating Scale (HAMD-17), Hamilton Anxiety Scale (HAMA), Interpersonal Comprehensive Diagnostic Scale (ICDS), Sheehan Disability Scale (SDS), and Morning and Evening Questionnaire (MEQ) at baseline and the 8th week.

Results: Compared to participants in IGP, participants in IRC had lower HAMD total scores, anxiety/somatization, weight, cognitive disturbance, retardation, and sleep disturbance subscores in patients with MDD (F = 190.94, p _Bonferroni < 0.001; F = 83.13, p _Bonferroni < 0.001; F = 4.15, p _Bonferroni = 0.048; F = 65.42, p _Bonferroni < 0.001; F = 53.15, p _Bonferroni < 0.001; F = 67.76, p _Bonferroni < 0.001, respectively); HAMA total score, somatic anxiety subscore, psychogenic anxiety subscore (F = 142.97, p _Bonferroni < 0.001; F = 111.06, p _Bonferroni < 0.001; F = 128.04, p _Bonferroni < 0.001); ICDS total score and subscores for conversation, making friends, manners; and SDS subscores for work/school, social life, family life, and days underproductive (F = 17.38, p _Bonferroni <0.001; F = 14.61, p _Bonferroni < 0.001; F = 10.97, p _Bonferroni = 0.001; F = 11.74, p _Bonferroni = 0.001; F = 4.85, p _Bonferroni = 0.031; F = 16.29, p _Bonferroni < 0.001; F = 12.11, p _Bonferroni = 0.001; F = 8.3, p _Bonferroni = 0.005) at the end of the intervention period.

Conclusions: IRC helped patients with MDD improve clinical symptoms, including depressive and anxiety symptoms, interpersonal problems, and social function.

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国际节律护理对抑郁症的疗效：随机对照试验。

研究目的本研究调查了节律间护理（IRC）对重度抑郁障碍（MDD）的疗效。目前还缺乏有关该疗法对抑郁症疗效的临床研究：在这项为期八周的随机、单盲、对照试验中，120 名重度抑郁症患者被随机分配接受 IRC 或互联网普通心理教育（IGP）。在基线期和第8周，使用17项汉密尔顿抑郁量表（HAMD-17）、汉密尔顿焦虑量表（HAMA）、人际关系综合诊断量表（ICDS）、希恩残疾量表（SDS）和晨昏问卷（MEQ）对参与者的抑郁和焦虑症状、人际关系、社会功能和生物节律进行评估：与 IGP 参与者相比，IRC 参与者在 MDD 患者中的 HAMD 总分、焦虑/焦躁、体重、认知障碍、发育迟缓和睡眠障碍分项得分较低（F = 190.94，p Bonferroni < 0.001；F = 83.13，p Bonferroni < 0.001；F = 4.15，p Bonferroni = 0.048；F = 65.42，p Bonferroni < 0.001；F = 53.15，p Bonferroni < 0.001；F = 67.76，p Bonferroni < 0.001）；HAMA 总分、躯体焦虑亚分、精神焦虑亚分（F = 142.97，p Bonferroni < 0.001；F = 111.06，p Bonferroni < 0.001；F = 128.04，p Bonferroni < 0.001）；ICDS 总分和谈话、交友、礼仪子分；SDS 工作/学校、社会生活、家庭生活和生产不足天数子分（F = 17.38，p Bonferroni Bonferroni < 0.001；F = 10.97，p Bonferroni = 0.001；F = 11.74，p Bonferroni = 0.001；F = 4.85，p Bonferroni = 0.031；F = 16.29，p Bonferroni < 0.001；F = 12.11，p Bonferroni = 0.001；F = 8.3，p Bonferroni = 0.005）：IRC帮助MDD患者改善了临床症状，包括抑郁和焦虑症状、人际交往问题和社会功能。

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来源期刊

Journal of psychiatric research 医学-精神病学

CiteScore

7.30

自引率

2.10%

发文量

622

审稿时长

130 days

期刊介绍： Founded in 1961 to report on the latest work in psychiatry and cognate disciplines, the Journal of Psychiatric Research is dedicated to innovative and timely studies of four important areas of research: (1) clinical studies of all disciplines relating to psychiatric illness, as well as normal human behaviour, including biochemical, physiological, genetic, environmental, social, psychological and epidemiological factors; (2) basic studies pertaining to psychiatry in such fields as neuropsychopharmacology, neuroendocrinology, electrophysiology, genetics, experimental psychology and epidemiology; (3) the growing application of clinical laboratory techniques in psychiatry, including imagery and spectroscopy of the brain, molecular biology and computer sciences;