Glymphatic system function in diverse glucose metabolism states.

IF 4.2 3区 医学 Q1 ENDOCRINOLOGY & METABOLISM World Journal of Diabetes Pub Date : 2024-11-15 DOI:10.4239/wjd.v15.i11.2245
Haewon Byeon
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Abstract

The rising prevalence of diabetes and prediabetes globally necessitates a deeper understanding of associated complications, including glymphatic system dysfunction. The glymphatic system, crucial for brain waste clearance, is implicated in cognitive decline and neurodegenerative diseases like Alzheimer's disease. This letter explores recent research on glymphatic function across different glucose metabolism states. Tian et al's study reveals significant glymphatic dysfunction in type 2 diabetes mellitus patients, evidenced by lower diffusion tensor imaging analysis along perivascular space indices compared to those with normal glucose metabolism and prediabetes. The research also reveals a link between glymphatic dysfunction and cognitive impairment. Additional research underscores the role of glymphatic impairment in neurodegenerative diseases. These findings highlight the importance of integrating glymphatic health into diabetes management and suggest potential biomarkers for early diagnosis and targeted therapeutic interventions.

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不同葡萄糖代谢状态下的淋巴系统功能。
全球糖尿病和糖尿病前期的发病率不断上升,因此有必要深入了解相关并发症,包括甘油系统功能障碍。甘液系统对清除大脑废物至关重要,与认知能力下降和阿尔茨海默病等神经退行性疾病有关。这封信探讨了不同葡萄糖代谢状态下甘油系统功能的最新研究。Tian等人的研究发现,与正常糖代谢和糖尿病前期患者相比,2型糖尿病患者的血管周围空间弥散张量成像分析指数较低,这证明2型糖尿病患者存在明显的糖代谢功能障碍。研究还揭示了糖代谢功能障碍与认知障碍之间的联系。其他研究强调了糖代谢障碍在神经退行性疾病中的作用。这些研究结果突显了将血糖健康纳入糖尿病管理的重要性,并为早期诊断和有针对性的治疗干预提出了潜在的生物标志物。
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来源期刊
World Journal of Diabetes
World Journal of Diabetes ENDOCRINOLOGY & METABOLISM-
自引率
2.40%
发文量
909
期刊介绍: The WJD is a high-quality, peer reviewed, open-access journal. The primary task of WJD is to rapidly publish high-quality original articles, reviews, editorials, and case reports in the field of diabetes. In order to promote productive academic communication, the peer review process for the WJD is transparent; to this end, all published manuscripts are accompanied by the anonymized reviewers’ comments as well as the authors’ responses. The primary aims of the WJD are to improve diagnostic, therapeutic and preventive modalities and the skills of clinicians and to guide clinical practice in diabetes. Scope: Diabetes Complications, Experimental Diabetes Mellitus, Type 1 Diabetes Mellitus, Type 2 Diabetes Mellitus, Diabetes, Gestational, Diabetic Angiopathies, Diabetic Cardiomyopathies, Diabetic Coma, Diabetic Ketoacidosis, Diabetic Nephropathies, Diabetic Neuropathies, Donohue Syndrome, Fetal Macrosomia, and Prediabetic State.
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