Clinical Management Update of Oral Leukoplakia: A Review From the American Head and Neck Society Cancer Prevention Service.

IF 2.3 3区医学 Q1 OTORHINOLARYNGOLOGY Head and Neck-Journal for the Sciences and Specialties of the Head and Neck Pub Date : 2024-11-25 DOI:10.1002/hed.28013

James C Gates, Marianne Abouyared, Yelizaveta Shnayder, D Gregory Farwell, Andrew Day, Faizan Alawi, Michael Moore, Andrew J Holcomb, Andrew Birkeland, Joel Epstein

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Abstract

Background: Oral potentially malignant disorders (OPMDs) occur in up to 4%-5% of the population, of which oral leukoplakia (OL) is the most common subtype. Predicting high-risk OL remains a challenge. Early diagnosis and effective treatment are thought to be of paramount importance to improve outcomes.

Methods: We searched PubMed and Clinicaltrials.gov data for updates in the clinical management of OL from 2015 to current.

Results: Recent publication of large cohorts of patients with OL aids in counseling patients regarding risk of malignant transformation. Management for OL includes surveillance, excision, and laser surgery, as well as local and systemic approaches to chemoprevention. Several new entities show promise regarding candidate biomarkers, chemoprevention agents, and diagnostic adjuncts, though all require further validation.

Conclusion: This update serves to further inform clinical management of OL and provide impetus for future investigations.

Trial registration: NCT00099021, NCT00951379, NCT05727761, NCT05727761.

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口腔白斑病的临床管理更新：美国头颈部协会癌症预防服务回顾。

背景：口腔潜在恶性疾病（OPMDs）的发病率高达 4%-5%，其中口腔白斑病（OL）是最常见的亚型。预测高风险口腔白斑病仍是一项挑战。早期诊断和有效治疗对改善预后至关重要：我们搜索了 PubMed 和 Clinicaltrials.gov 数据，以了解 2015 年至今 OL 临床治疗的最新进展：最近发表的大型OL患者队列有助于为患者提供有关恶性转化风险的咨询。OL的治疗包括监测、切除和激光手术，以及局部和全身的化学预防方法。一些新的实体显示出候选生物标志物、化学预防药物和诊断辅助手段的前景，但所有这些都需要进一步验证：结论：这一更新有助于进一步为 OL 的临床管理提供信息，并为未来的研究提供动力：NCT00099021、NCT00951379、NCT05727761、NCT05727761。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Head and Neck-Journal for the Sciences and Specialties of the Head and Neck 医学-耳鼻喉科学

CiteScore

7.00

自引率

6.90%

发文量

278

审稿时长

1.6 months

期刊介绍： Head & Neck is an international multidisciplinary publication of original contributions concerning the diagnosis and management of diseases of the head and neck. This area involves the overlapping interests and expertise of several surgical and medical specialties, including general surgery, neurosurgery, otolaryngology, plastic surgery, oral surgery, dermatology, ophthalmology, pathology, radiotherapy, medical oncology, and the corresponding basic sciences.