Elevated locus coeruleus metabolism provides resilience against cognitive decline in preclinical Alzheimer's disease

IF 11.1 1区医学 Q1 CLINICAL NEUROLOGY Alzheimer's & Dementia Pub Date : 2024-11-26 DOI:10.1002/alz.14385

Elouise A. Koops, Joyita Dutta, Bernard J. Hanseeuw, J. Alex Becker, Maxime Van Egroo, Prokopis C. Prokopiou, Julie C. Price, Steven E. Arnold, Reisa A. Sperling, Keith A. Johnson, Heidi I. L. Jacobs, for the Alzheimer's Disease Neuroimaging Initiative

{"title":"Elevated locus coeruleus metabolism provides resilience against cognitive decline in preclinical Alzheimer's disease","authors":"Elouise A. Koops, Joyita Dutta, Bernard J. Hanseeuw, J. Alex Becker, Maxime Van Egroo, Prokopis C. Prokopiou, Julie C. Price, Steven E. Arnold, Reisa A. Sperling, Keith A. Johnson, Heidi I. L. Jacobs, for the Alzheimer's Disease Neuroimaging Initiative","doi":"10.1002/alz.14385","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> INTRODUCTION</h3>\n \n <p>Alterations in locus coeruleus’ (LC) metabolic turnover are associated with Alzheimer's disease (AD)-pathology and cognitive impairment. However, the evolution of these changes across disease stages and their functional relevance remains unknown.</p>\n </section>\n \n <section>\n \n <h3> METHODS</h3>\n \n <p>We examined associations of [<sup>18</sup>F]-fluorodeoxyglucose positron emission tomography (FDG-PET) -derived LC metabolism with clinical diagnostic status, cerebrospinal fluid (CSF) -based AD biomarkers of AD pathology, and cognitive decline in Alzheimer's Disease Neuroimaging Initiative (ADNI) participants (<i>n</i> = 604).</p>\n </section>\n \n <section>\n \n <h3> RESULTS</h3>\n \n <p>FDG-PET-derived LC metabolism was elevated in the earliest preclinical stages and lower in later disease stages. Higher LC metabolism was associated with attenuated memory decline in preclinical stages, particularly in those with low CSF Aβ<sub>42,</sub> but not in AD patients with cognitive impairment.</p>\n </section>\n \n <section>\n \n <h3> DISCUSSION</h3>\n \n <p>Higher locus coeruleus [<sup>18</sup>F]-FDG-PET-derived signal in the early preclinical stages of AD can confer cognitive resilience and may reflect increased metabolic activity, whereas later stages are characterized by lower LC FDG-PET-derived signal, possibly due to neurodegeneration.</p>\n </section>\n \n <section>\n \n <h3> Highlights</h3>\n \n <div>\n <ul>\n \n <li>LC FDG-PET signal is lower in Alzheimer's disease (AD) patients.</li>\n \n <li>LC FDG-PET signal is higher in the preclinical stage of AD.</li>\n \n <li>We observed less memory decline in those with higher LC FDG-PET signal.</li>\n \n <li>Higher LC FDG-PET signal conferred cognitive resilience in preclinical AD.</li>\n </ul>\n </div>\n </section>\n </div>","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"21 1","pages":""},"PeriodicalIF":11.1000,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/alz.14385","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Alzheimer's & Dementia","FirstCategoryId":"3","ListUrlMain":"https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.14385","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

INTRODUCTION

Alterations in locus coeruleus’ (LC) metabolic turnover are associated with Alzheimer's disease (AD)-pathology and cognitive impairment. However, the evolution of these changes across disease stages and their functional relevance remains unknown.

METHODS

We examined associations of [¹⁸F]-fluorodeoxyglucose positron emission tomography (FDG-PET) -derived LC metabolism with clinical diagnostic status, cerebrospinal fluid (CSF) -based AD biomarkers of AD pathology, and cognitive decline in Alzheimer's Disease Neuroimaging Initiative (ADNI) participants (n = 604).

RESULTS

FDG-PET-derived LC metabolism was elevated in the earliest preclinical stages and lower in later disease stages. Higher LC metabolism was associated with attenuated memory decline in preclinical stages, particularly in those with low CSF Aβ_42, but not in AD patients with cognitive impairment.

DISCUSSION

Higher locus coeruleus [¹⁸F]-FDG-PET-derived signal in the early preclinical stages of AD can confer cognitive resilience and may reflect increased metabolic activity, whereas later stages are characterized by lower LC FDG-PET-derived signal, possibly due to neurodegeneration.

Highlights

LC FDG-PET signal is lower in Alzheimer's disease (AD) patients.
LC FDG-PET signal is higher in the preclinical stage of AD.
We observed less memory decline in those with higher LC FDG-PET signal.
Higher LC FDG-PET signal conferred cognitive resilience in preclinical AD.

Abstract Image

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

在临床前阿尔茨海默氏症患者中，局部小脑代谢的升高可抵御认知能力的下降

脑室（LC）代谢周转的改变与阿尔茨海默病（AD）的病理和认知障碍有关。然而，这些变化在不同疾病阶段的演变及其功能相关性仍然未知。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Alzheimer's & Dementia 医学-临床神经学

CiteScore

14.50

自引率

5.00%

发文量

299

审稿时长

3 months

期刊介绍： Alzheimer's & Dementia is a peer-reviewed journal that aims to bridge knowledge gaps in dementia research by covering the entire spectrum, from basic science to clinical trials to social and behavioral investigations. It provides a platform for rapid communication of new findings and ideas, optimal translation of research into practical applications, increasing knowledge across diverse disciplines for early detection, diagnosis, and intervention, and identifying promising new research directions. In July 2008, Alzheimer's & Dementia was accepted for indexing by MEDLINE, recognizing its scientific merit and contribution to Alzheimer's research.