Elouise A. Koops, Joyita Dutta, Bernard J. Hanseeuw, J. Alex Becker, Maxime Van Egroo, Prokopis C. Prokopiou, Julie C. Price, Steven E. Arnold, Reisa A. Sperling, Keith A. Johnson, Heidi I. L. Jacobs
{"title":"Elevated locus coeruleus metabolism provides resilience against cognitive decline in preclinical Alzheimer's disease","authors":"Elouise A. Koops, Joyita Dutta, Bernard J. Hanseeuw, J. Alex Becker, Maxime Van Egroo, Prokopis C. Prokopiou, Julie C. Price, Steven E. Arnold, Reisa A. Sperling, Keith A. Johnson, Heidi I. L. Jacobs","doi":"10.1002/alz.14385","DOIUrl":null,"url":null,"abstract":"Alterations in locus coeruleus’ (LC) metabolic turnover are associated with Alzheimer's disease (AD)-pathology and cognitive impairment. However, the evolution of these changes across disease stages and their functional relevance remains unknown.","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"85 1","pages":""},"PeriodicalIF":13.0000,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Alzheimer's & Dementia","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1002/alz.14385","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Alterations in locus coeruleus’ (LC) metabolic turnover are associated with Alzheimer's disease (AD)-pathology and cognitive impairment. However, the evolution of these changes across disease stages and their functional relevance remains unknown.
期刊介绍：
Alzheimer's & Dementia is a peer-reviewed journal that aims to bridge knowledge gaps in dementia research by covering the entire spectrum, from basic science to clinical trials to social and behavioral investigations. It provides a platform for rapid communication of new findings and ideas, optimal translation of research into practical applications, increasing knowledge across diverse disciplines for early detection, diagnosis, and intervention, and identifying promising new research directions. In July 2008, Alzheimer's & Dementia was accepted for indexing by MEDLINE, recognizing its scientific merit and contribution to Alzheimer's research.
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