MDIG in Breast Cancer Progression and Metastasis.

Abstract

Breast cancer is the most diagnosed cancer among women worldwide, and metastasis remains the major cause of breast cancer-related mortality and is associated with poor patient outcomes. Among breast cancers, triple-negative breast cancers have the worst prognosis owing to their highly aggressive and metastasizing attributes and hence have limited therapeutic options. Here, we have presented our research on an environmentally regulated gene named mdig and its role in the pathogenesis of breast cancer and metastasis. Through global proteomics, chromatin immunoprecipitation sequencing, and a mouse model of orthotopic xenograft, our studies established mdig as an anti-metastasis modulator in breast cancer with its influence on the methylation of DNA and histone proteins, thereby regulating the expression of genes implicated in epithelial-mesenchymal transitional, cell motility, and metastasis.