Fusobacterium nucleatum Abundance is Associated with Cachexia in Colorectal Cancer Patients: The ColoCare Study.

IF 2.9 2区医学 Q2 ONCOLOGY Cancer Medicine Pub Date : 2024-11-01 DOI:10.1002/cam4.70431

Mmadili N Ilozumba, Tengda Lin, Sheetal Hardikar, Doratha A Byrd, June L Round, W Zac Stephens, Andreana N Holowatyj, Christy A Warby, Victoria Damerell, Christopher I Li, Jane C Figueiredo, Adetunji T Toriola, David Shibata, Gary C Fillmore, Bartley Pickron, Erin M Siegel, Christoph Kahlert, Vaia Florou, Biljana Gigic, Jennifer Ose, Cornelia M Ulrich

{"title":"Fusobacterium nucleatum Abundance is Associated with Cachexia in Colorectal Cancer Patients: The ColoCare Study.","authors":"Mmadili N Ilozumba, Tengda Lin, Sheetal Hardikar, Doratha A Byrd, June L Round, W Zac Stephens, Andreana N Holowatyj, Christy A Warby, Victoria Damerell, Christopher I Li, Jane C Figueiredo, Adetunji T Toriola, David Shibata, Gary C Fillmore, Bartley Pickron, Erin M Siegel, Christoph Kahlert, Vaia Florou, Biljana Gigic, Jennifer Ose, Cornelia M Ulrich","doi":"10.1002/cam4.70431","DOIUrl":null,"url":null,"abstract":"Background: Cachexia accounts for about 20% of all cancer-related deaths and indicates poor prognosis. The impact of Fusobacterium nucleatum (Fn), a microbial risk factor for colorectal cancer (CRC), on the development of cachexia in CRC has not been established.Methods: We evaluated the association between Fn abundance in pre-surgical stool samples and onset of cachexia at 6 months post-surgery in n = 87 patients with stages I-III CRC in the ColoCare Study.Results: High fecal Fn abundance compared to negative/low fecal Fn abundance was associated with 4-fold increased risk of cachexia onset at 6 months post-surgery (OR = 4.82, 95% CI = 1.15, 20.10, p = 0.03).Conclusion: Our findings suggest that high fecal Fn abundance was associated with an increased risk of cachexia at 6 months post-surgery in CRC patients. This is the first study to link Fn abundance with cachexia in CRC patients, offering novel insights into biological mechanisms and potential management of cancer cachexia. Due to the small sample size, our results should be interpreted with caution. Future studies with larger sample sizes are needed to validate these findings.","PeriodicalId":139,"journal":{"name":"Cancer Medicine","volume":"13 22","pages":"e70431"},"PeriodicalIF":2.9000,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cancer Medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1002/cam4.70431","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ONCOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Background: Cachexia accounts for about 20% of all cancer-related deaths and indicates poor prognosis. The impact of Fusobacterium nucleatum (Fn), a microbial risk factor for colorectal cancer (CRC), on the development of cachexia in CRC has not been established.

Methods: We evaluated the association between Fn abundance in pre-surgical stool samples and onset of cachexia at 6 months post-surgery in n = 87 patients with stages I-III CRC in the ColoCare Study.

Results: High fecal Fn abundance compared to negative/low fecal Fn abundance was associated with 4-fold increased risk of cachexia onset at 6 months post-surgery (OR = 4.82, 95% CI = 1.15, 20.10, p = 0.03).

Conclusion: Our findings suggest that high fecal Fn abundance was associated with an increased risk of cachexia at 6 months post-surgery in CRC patients. This is the first study to link Fn abundance with cachexia in CRC patients, offering novel insights into biological mechanisms and potential management of cancer cachexia. Due to the small sample size, our results should be interpreted with caution. Future studies with larger sample sizes are needed to validate these findings.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

核酸分枝杆菌的丰度与结直肠癌患者的恶病质有关：结直肠癌护理研究

背景：恶病质约占所有癌症相关死亡的 20%，预示着不良预后。Fusobacterium nucleatum（Fn）是结直肠癌（CRC）的微生物风险因子，它对 CRC 恶病质发生的影响尚未确定：我们评估了ColoCare研究中87名I-III期CRC患者手术前粪便样本中Fn丰度与术后6个月恶病质发生之间的关系：结果：与阴性/低粪便Fn丰度相比，高粪便Fn丰度与手术后6个月恶病质发生风险增加4倍相关（OR = 4.82，95% CI = 1.15，20.10，p = 0.03）：我们的研究结果表明，高粪便Fn丰度与CRC患者术后6个月出现恶病质的风险增加有关。这是第一项将 Fn 丰度与 CRC 患者恶病质联系起来的研究，为癌症恶病质的生物学机制和潜在管理提供了新的见解。由于样本量较小，在解释我们的结果时应谨慎。未来需要更大样本量的研究来验证这些发现。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Cancer Medicine ONCOLOGY-

CiteScore

5.50

自引率

2.50%

发文量

907

审稿时长

19 weeks

期刊介绍： Cancer Medicine is a peer-reviewed, open access, interdisciplinary journal providing rapid publication of research from global biomedical researchers across the cancer sciences. The journal will consider submissions from all oncologic specialties, including, but not limited to, the following areas: Clinical Cancer Research Translational research ∙ clinical trials ∙ chemotherapy ∙ radiation therapy ∙ surgical therapy ∙ clinical observations ∙ clinical guidelines ∙ genetic consultation ∙ ethical considerations Cancer Biology: Molecular biology ∙ cellular biology ∙ molecular genetics ∙ genomics ∙ immunology ∙ epigenetics ∙ metabolic studies ∙ proteomics ∙ cytopathology ∙ carcinogenesis ∙ drug discovery and delivery. Cancer Prevention: Behavioral science ∙ psychosocial studies ∙ screening ∙ nutrition ∙ epidemiology and prevention ∙ community outreach. Bioinformatics: Gene expressions profiles ∙ gene regulation networks ∙ genome bioinformatics ∙ pathwayanalysis ∙ prognostic biomarkers. Cancer Medicine publishes original research articles, systematic reviews, meta-analyses, and research methods papers, along with invited editorials and commentaries. Original research papers must report well-conducted research with conclusions supported by the data presented in the paper.