Relationship Between Alzheimer Disease Imaging Biomarkers and Performance on the NIH Toolbox Cognition Battery in Late-middle Age Hispanics.

IF 1.8 4区医学 Q3 CLINICAL NEUROLOGY Alzheimer Disease & Associated Disorders Pub Date : 2024-10-01 Epub Date: 2024-11-26 DOI:10.1097/WAD.0000000000000641

Mouna Tahmi, Brady Rippon, Priya Palta, Greysi Sherwood, Gabriela Hernandez, Luisa Soto, Sandino Cespedes, Michelle Pardo, Krystal Laing, Kay Igwe, Aubrey Johnson, Zeljko Tomljanovic, Hengda He, José Gutierrez, Jeanne A Teresi, Herman Moreno, William Kreisl, Qolamreza Razlighi, Adam M Brickman, José A Luchsinger

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Abstract

Purpose: The National Institute of Health Toolbox Cognition Battery (NIHTB-CB) is increasingly used in Alzheimer disease (AD) research. We examined the relation of AD biomarkers with performance in the NIHTB-CB in late middle age.

Methods: This is a cross-sectional analysis of 334 Hispanic participants aged 64.22±3.35 years from a study of AD biomarkers. White matter hyperintensities (WMH), infarcts, and cortical thickness in AD regions (CT) were assessed with 3T magnetic resonance imaging. Amyloid and tau were assessed with 18F-Florbetaben and 18F-MK6240 positron emission tomography, respectively.

Results: Lower CT and infarcts were associated with worse Oral Reading Recognition and Cognition Crystallized Composite scores. Lower CT and higher WMH were associated with worse Pattern Comparison Processing Speed. Amyloid and tau were not associated with any test.

Discussion: Amyloid and tau, the culprits of AD, are not related to the NIHTB-CB in late middle age. Continued follow-up will reveal if AD impacts performance on the NIHTB-CB.

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中晚年西班牙裔阿尔茨海默病成像生物标志物与 NIH 工具箱认知能力测试成绩之间的关系

目的：美国国立卫生研究院工具箱认知测验（NIHTB-CB）越来越多地用于阿尔茨海默病（AD）研究。我们研究了中年晚期阿尔茨海默病生物标志物与 NIHTB-CB 成绩的关系：这是一项横断面分析，研究对象是一项 AD 生物标记物研究中的 334 名年龄为（64.22±3.35）岁的西班牙裔参与者。3T磁共振成像评估了AD区域（CT）的白质高密度（WMH）、梗死和皮质厚度。淀粉样蛋白和tau分别通过18F-氟贝特本和18F-MK6240正电子发射断层扫描进行评估：较低的 CT 和梗死与较差的口头阅读识别和认知结晶综合评分有关。较低的 CT 值和较高的 WMH 与较差的模式比较处理速度有关。淀粉样蛋白和tau与任何测试均无关联：讨论：AD的罪魁祸首淀粉样蛋白和tau与中年后期的NIHTB-CB无关。继续随访将揭示注意力缺失症是否会影响 NIHTB-CB 的表现。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Alzheimer Disease & Associated Disorders 医学-病理学

CiteScore

3.10

自引率

4.80%

发文量

期刊介绍： Alzheimer Disease & Associated Disorders is a peer-reviewed, multidisciplinary journal directed to an audience of clinicians and researchers, with primary emphasis on Alzheimer disease and associated disorders. The journal publishes original articles emphasizing research in humans including epidemiologic studies, clinical trials and experimental studies, studies of diagnosis and biomarkers, as well as research on the health of persons with dementia and their caregivers. The scientific portion of the journal is augmented by reviews of the current literature, concepts, conjectures, and hypotheses in dementia, brief reports, and letters to the editor.