Prognostic value of mechanical dyssynchrony in patients with heart failure: a systematic review.

IF 2 3区医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS BMC Cardiovascular Disorders Pub Date : 2024-11-26 DOI:10.1186/s12872-024-04360-6

Ziqi Chen, Qiang Qu, Iokfai Cheang, Xinyi Lu, Shengen Liao, Rongrong Gao, Yanli Zhou, Xinli Li

{"title":"Prognostic value of mechanical dyssynchrony in patients with heart failure: a systematic review.","authors":"Ziqi Chen, Qiang Qu, Iokfai Cheang, Xinyi Lu, Shengen Liao, Rongrong Gao, Yanli Zhou, Xinli Li","doi":"10.1186/s12872-024-04360-6","DOIUrl":null,"url":null,"abstract":"Background: Heart failure (HF) significantly impacts quality of life and healthcare systems worldwide. Assessing left ventricular mechanical dyssynchrony (LVMD) is crucial for understanding cardiac function and optimizing treatments like cardiac resynchronization therapy (CRT). Phase analysis using gated single-photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) has shown promise in predicting outcomes, yet recent comprehensive reviews are lacking.Objective: To systematically assess the prognostic value of phase analysis by gated SPECT MPI in the HF population through a systematic review.Methods: We conducted a systematic review by collecting studies from databases including PubMed, CINAHL, and Web of Science. Two reviewers independently performed study selection, data extraction, and risk of bias assessment. Systematic reviews were conducted using Review Manager Software 5.4 and STATA 16.0.Results: A total of 2004 patients from seven studies were included in our review and analysis. The systematic review indicated that patients with predetermined clinical events had higher PSD [MD = 6.45, 95% CI (5.83, 7.07), p < 0.00001] and PBW [MD = 7.91, 95% CI (5.64, 10.19), p < 0.00001]. The diagnosis of LVMD determined by PSD [HR = 1.05, 95% CI (1.01, 1.08), p = 0.007] was a strong predictor of endpoint events compared to PBW [HR = 1.95, 95% CI (0.48, 7.89), p = 0.35].Conclusions: The analysis demonstrated that phase information obtained from gated SPECT MPI is of significant prognostic value in patients with heart dysfunction. It effectively enhances clinical risk models, providing reliable guidance for patient treatment.","PeriodicalId":9195,"journal":{"name":"BMC Cardiovascular Disorders","volume":"24 1","pages":"674"},"PeriodicalIF":2.0000,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11590517/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"BMC Cardiovascular Disorders","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1186/s12872-024-04360-6","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}

引用次数: 0

Abstract

Background: Heart failure (HF) significantly impacts quality of life and healthcare systems worldwide. Assessing left ventricular mechanical dyssynchrony (LVMD) is crucial for understanding cardiac function and optimizing treatments like cardiac resynchronization therapy (CRT). Phase analysis using gated single-photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) has shown promise in predicting outcomes, yet recent comprehensive reviews are lacking.

Objective: To systematically assess the prognostic value of phase analysis by gated SPECT MPI in the HF population through a systematic review.

Methods: We conducted a systematic review by collecting studies from databases including PubMed, CINAHL, and Web of Science. Two reviewers independently performed study selection, data extraction, and risk of bias assessment. Systematic reviews were conducted using Review Manager Software 5.4 and STATA 16.0.

Results: A total of 2004 patients from seven studies were included in our review and analysis. The systematic review indicated that patients with predetermined clinical events had higher PSD [MD = 6.45, 95% CI (5.83, 7.07), p < 0.00001] and PBW [MD = 7.91, 95% CI (5.64, 10.19), p < 0.00001]. The diagnosis of LVMD determined by PSD [HR = 1.05, 95% CI (1.01, 1.08), p = 0.007] was a strong predictor of endpoint events compared to PBW [HR = 1.95, 95% CI (0.48, 7.89), p = 0.35].

Conclusions: The analysis demonstrated that phase information obtained from gated SPECT MPI is of significant prognostic value in patients with heart dysfunction. It effectively enhances clinical risk models, providing reliable guidance for patient treatment.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

心力衰竭患者机械不同步的预后价值：系统综述。

背景：心力衰竭（HF心力衰竭（HF）严重影响着全世界的生活质量和医疗系统。评估左心室机械不同步（LVMD）对于了解心脏功能和优化心脏再同步化治疗（CRT）等治疗方法至关重要。使用门控单光子发射计算机断层扫描（SPECT）心肌灌注成像（MPI）进行相位分析已显示出预测预后的前景，但近期缺乏全面的综述：目的：通过系统性综述系统评估门控 SPECT MPI 相位分析在高频人群中的预后价值：我们从 PubMed、CINAHL 和 Web of Science 等数据库中收集了相关研究，并进行了系统性综述。两名审稿人独立完成了研究选择、数据提取和偏倚风险评估。系统性综述使用综述管理软件 5.4 和 STATA 16.0 进行：共有来自 7 项研究的 2004 名患者纳入了我们的综述和分析。系统综述显示，有预定临床事件的患者的 PSD 较高[MD = 6.45，95% CI (5.83，7.07)，p 结论：系统综述显示，有预定临床事件的患者的 PSD 较低：分析表明，门控 SPECT MPI 获得的相位信息对心功能不全患者的预后具有重要价值。它能有效增强临床风险模型，为患者治疗提供可靠的指导。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

BMC Cardiovascular Disorders CARDIAC & CARDIOVASCULAR SYSTEMS-

CiteScore

3.50

自引率

0.00%

发文量

480

审稿时长

1 months

期刊介绍： BMC Cardiovascular Disorders is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of disorders of the heart and circulatory system, as well as related molecular and cell biology, genetics, pathophysiology, epidemiology, and controlled trials.