Lipid nanocarrier-based bigel of Piper betel oil for analgesic and anti-inflammatory applications.

IF 3 4区医学 Q2 CHEMISTRY, APPLIED Journal of microencapsulation Pub Date : 2024-11-25 DOI:10.1080/02652048.2024.2430651

Bhabani Sankar Satapathy, Abhishek Mishra, Kritika Mohanty, Snigdha Pattnaik, Shyamalendu Tripathy, Biswabhusan Biswal

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Abstract

Present study reports analgesic and anti-inflammatory potential of Piper betel (L.) leaf oil loaded lipid nanocarrier (BLNs)-embedded bigel. BLNs were developed by solvent evaporation technique and were characterised by FESEM, Cryo-TEM, mean diameter, zeta potential, loading efficiency, etc. BLNs embedded bigel (BLNs-G) was evaluated for analgesic and anti-inflammatory efficacy in rat model. Data showed spherical BLNs with intact lamellarity, 138.2 ± 1.08 nm mean diameter, 0.182 PDI, -46.6 ± 0.61 mV zeta potential, 76.2 ± 2.1% (w/w) loading efficiency and a sustained release in vitro. BLNs-G was homogenous with satisfied viscosity (40 734 ± 1.7 cps), spreadability (8.3 ± 1.5 g.cm sec^-1), extrudability (91.33 ± 1.3% w/w) along with a sustained permeation ex vivo. Significant analgesic and anti-inflammatory action were depicted by BLNs-G (1% w/w) in rat model (p ˂ 0.05) within 30 minutes post topical application. In silico docking study revealed high affinity of major phytoactive components with key analgesic/inflammatory mediators. Further pre-clinical investigations are warranted for futuristic clinical application of BLNs-G.

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基于脂质纳米载体的胡椒槟榔油镇痛消炎应用。

本研究报告了含槟榔叶脂质纳米载体（BLNs）的槟榔叶镇痛和抗炎潜力。BLNs 采用溶剂蒸发技术开发，并通过 FESEM、Cryo-TEM、平均直径、Zeta 电位、负载效率等进行表征。在大鼠模型中评估了嵌入 bigel 的 BLNs（BLNs-G）的镇痛和抗炎功效。数据显示，BLNs-G 为球形，具有完整的层状结构，平均直径为 138.2 ± 1.08 nm，PDI 为 0.182，Zeta 电位为 -46.6 ± 0.61 mV，负载效率为 76.2 ± 2.1%（w/w），体外可持续释放。BLNs-G 具有均匀的粘度（40 734 ± 1.7 cps）、铺展性（8.3 ± 1.5 g.cm sec-1）和挤出性（91.33 ± 1.3% w/w），并具有体内持续渗透性。在大鼠模型中，BLNs-G（1% w/w）在局部使用后 30 分钟内具有显著的镇痛和抗炎作用（p ˂ 0.05）。硅学对接研究显示，主要植物活性成分与关键的镇痛/炎症介质具有很高的亲和力。有必要对 BLNs-G 的未来临床应用进行进一步的临床前研究。

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来源期刊

Journal of microencapsulation 工程技术-工程：化工

CiteScore

6.30

自引率

2.60%

发文量

审稿时长

3 months

期刊介绍： The Journal of Microencapsulation is a well-established, peer-reviewed journal dedicated to the publication of original research findings related to the preparation, properties and uses of individually encapsulated novel small particles, as well as significant improvements to tried-and-tested techniques relevant to micro and nano particles and their use in a wide variety of industrial, engineering, pharmaceutical, biotechnology and research applications. Its scope extends beyond conventional microcapsules to all other small particulate systems such as self assembling structures that involve preparative manipulation. The journal covers: Chemistry of encapsulation materials Physics of release through the capsule wall and/or desorption from carrier Techniques of preparation, content and storage Many uses to which microcapsules are put.