Incidence of infective endocarditis in patients with hypertrophic cardiomyopathy.

IF 1.4 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS Indian heart journal Pub Date : 2024-11-24 DOI:10.1016/j.ihj.2024.11.332

Somyata Somendra, Saurabh Mehrotra, Parag Barwad, Himanshu Gupta, Ajay Bahl

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Abstract

Background: Data on the incidence of infective endocarditis (IE) in patients with hypertrophic cardiomyopathy (HCM) is sparse. This study evaluated a HCM cohort with aim to study the incidence of IE in these patients.

Methods: All patients entering the HCM cohort from May 2003 to June 2022 of a tertiary care hospital with at least one follow-up visit were included and followed up till June 2023. This was a retrospective cohort analysis. Only individuals who were diagnosed with IE after entry into the cohort were included.

Results: The study cohort consisted of 529 HCM patients with a total follow up duration of 3244.6 years. The mean and median follow-up durations were 6.1 ± 4.7 and 5.3 (range 31 days to 20.1) years respectively. Three (0.57 %) patients in the cohort developed IE. Incidence of IE in HCM patients was 0.92/1000 patient years. Two patients had left ventricular outflow tract obstruction while one had non-obstructive HCM. None of the patients with isolated mid-cavity gradients developed IE. The incidence of IE in the obstructive and nonobstructive groups was 1.39 and 0.55 per 1000 patient years respectively. Two had vegetations on mitral valve while one had vegetations on aortic valve. Both patients with mitral valve endocarditis developed severe residual mitral regurgitation and heart failure.

Conclusions: IE is a rare complication in HCM patients with an incidence of 0.92/1000 patient years. However, when it occurs, IE is associated with high morbidity and mortality.

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肥厚型心肌病患者感染性心内膜炎的发病率。

背景：有关肥厚型心肌病（HCM）患者感染性心内膜炎（IE）发病率的数据很少。本研究对肥厚型心肌病队列进行了评估，旨在研究这些患者的感染性心内膜炎发病率：方法：纳入 2003 年 5 月至 2022 年 6 月在一家三级医院就诊并至少接受过一次随访的所有 HCM 患者，并随访至 2023 年 6 月。这是一项回顾性队列分析。只有在进入队列后被确诊为 IE 的患者才被纳入：研究队列由 529 名 HCM 患者组成，总随访时间为 3244.6 年。平均和中位随访时间分别为 6.1 ± 4.7 年和 5.3 年（31 天至 20.1 年不等）。队列中有三名患者（0.57%）发生了 IE。HCM 患者的 IE 发生率为 0.92/1000 患者年。两名患者患有左心室流出道梗阻，一名患者患有非梗阻性 HCM。孤立中腔梯度患者中没有一人发生 IE。阻塞组和非阻塞组的 IE 发生率分别为每 1000 患者年 1.39 例和 0.55 例。两名患者的二尖瓣上长有植被，一名患者的主动脉瓣上长有植被。两名二尖瓣心内膜炎患者都出现了严重的二尖瓣残余反流和心力衰竭：二尖瓣内膜炎在 HCM 患者中是一种罕见的并发症，发病率为 0.92/1000。然而，一旦发生，IE 的发病率和死亡率都很高。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Indian heart journal CARDIAC & CARDIOVASCULAR SYSTEMS-

CiteScore

2.60

自引率

6.70%

发文量

审稿时长

52 days

期刊介绍： Indian Heart Journal (IHJ) is the official peer-reviewed open access journal of Cardiological Society of India and accepts articles for publication from across the globe. The journal aims to promote high quality research and serve as a platform for dissemination of scientific information in cardiology with particular focus on South Asia. The journal aims to publish cutting edge research in the field of clinical as well as non-clinical cardiology - including cardiovascular medicine and surgery. Some of the topics covered are Heart Failure, Coronary Artery Disease, Hypertension, Interventional Cardiology, Cardiac Surgery, Valvular Heart Disease, Pulmonary Hypertension and Infective Endocarditis. IHJ open access invites original research articles, research briefs, perspective, case reports, case vignette, cardiovascular images, cardiovascular graphics, research letters, correspondence, reader forum, and interesting photographs, for publication. IHJ open access also publishes theme-based special issues and abstracts of papers presented at the annual conference of the Cardiological Society of India.