Prevalence of HLA-B*58:01 allele among Malay, Chinese and Indian ethnic patients with gout attending primary care clinics in Malaysia.

IF 1.5 Q4 GENETICS & HEREDITY Journal of Community Genetics Pub Date : 2024-11-25 DOI:10.1007/s12687-024-00753-4
Wei Leik Ng, Boon Pin Kee, Norita Hussein, Chirk Jenn Ng, Sheh Wen Kuan, Fatimah Zahrah Mohd Zaidan, Siti Umi Fairuz Azmi, Sue-Mian Then, Zhenli Kwan, Nadeem Qureshi, Jing Ran Lim, Li Ying Wong, Yew Kong Lee, Tun Firzara Abdul Malik, Rajeswari Gunasekaran, Dyoi-E Low
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Abstract

HLA-B*58:01 allele is associated with allopurinol-induced severe cutaneous reaction (SCAR). Malaysia has a multiethnic population with limited data on the prevalence of HLA-B*58:01 among patients with gout treated in primary care settings. This cross-sectional study aimed to determine the prevalence of HLA-B*5801 in patients with gout from the Malay, Chinese and Indian ethnicities attending primary clinics in Malaysia.We collected blood samples from patients with gout attending three primary care clinics in Klang Valley, Malaysia, using convenience sampling. Genomic DNA samples were subjected to typing of HLA-B*5801 by a multiplex probe-based assay in a real-time PCR system, validated by PCR-resequencing approach.547 patients (194 Malay, 266 Chinese and 87 Indian) were recruited. The overall prevalence of HLA-B*58:01 was 16.8% (Chinese 21.8%, Indian 12.6% and Malay 11.9%). None of our 61 HLA-B*58:01 carriers who ever used allopurinol developed SCAR.The overall prevalence of HLA-B*58:01 allele in our patients with gout was high, particularly among the Chinese ethnicity (21.8%). None of our HLA-B*58:01 positive patients treated with allopurinol reported allopurinol-induced SCAR. A more accurate predictive model for allopurinol-induced SCAR is needed.

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在马来西亚初级保健诊所就诊的马来人、华人和印度裔痛风患者中 HLA-B*58:01 等位基因的流行率。
HLA-B*58:01等位基因与别嘌呤醇诱发的严重皮肤反应(SCAR)有关。马来西亚是一个多民族国家,在初级医疗机构接受治疗的痛风患者中,HLA-B*58:01 的患病率数据有限。这项横断面研究旨在确定在马来西亚初级诊所就诊的马来族、华族和印度族痛风患者中 HLA-B*5801 的患病率。基因组 DNA 样本通过实时 PCR 系统中的多重探针法进行 HLA-B*5801 分型,并通过 PCR 测序法进行验证。547 名患者(194 名马来人、266 名华人和 87 名印度人)中,HLA-B*58:01 的总患病率为 16.8%(华人 21.8%、印度人 12.6%、马来人 11.9%)。61名曾使用别嘌醇的HLA-B*58:01等位基因携带者中,无一人罹患SCAR。在接受别嘌呤醇治疗的 HLA-B*58:01 阳性患者中,没有一人报告别嘌呤醇诱发 SCAR。我们需要一个更准确的别嘌呤醇诱发 SCAR 的预测模型。
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来源期刊
Journal of Community Genetics
Journal of Community Genetics GENETICS & HEREDITY-
CiteScore
3.30
自引率
5.30%
发文量
54
期刊介绍: The Journal of Community Genetics is an international forum for research in the ever-expanding field of community genetics, the art and science of applying medical genetics to human communities for the benefit of their individuals. Community genetics comprises all activities which identify persons at increased genetic risk and has an interest in assessing this risk, in order to enable those at risk to make informed decisions. Community genetics services thus encompass such activities as genetic screening, registration of genetic conditions in the population, routine preconceptional and prenatal genetic consultations, public education on genetic issues, and public debate on related ethical issues. The Journal of Community Genetics has a multidisciplinary scope. It covers medical genetics, epidemiology, genetics in primary care, public health aspects of genetics, and ethical, legal, social and economic issues. Its intention is to serve as a forum for community genetics worldwide, with a focus on low- and middle-income countries. The journal features original research papers, reviews, short communications, program reports, news, and correspondence. Program reports describe illustrative projects in the field of community genetics, e.g., design and progress of an educational program or the protocol and achievement of a gene bank. Case reports describing individual patients are not accepted.
期刊最新文献
Knowledge and attitudes towards genomic medicine and pharmacogenomics of medical undergraduate students in Sri Lanka: a cross-sectional study. Prevalence of HLA-B*58:01 allele among Malay, Chinese and Indian ethnic patients with gout attending primary care clinics in Malaysia. Engaging communities: A scoping literature review of community-based participatory research in genetics service delivery settings. Population molecular genetics in Brazil: From genomic databases and research to the implementation of precision medicine. Knowledge and perception of medical students on genetics in the genomic era.
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