Microbe Profile: Candida glabrata - a master of deception.

IF 2.6 4区 生物学 Q3 MICROBIOLOGY Microbiology-Sgm Pub Date : 2024-11-01 DOI:10.1099/mic.0.001518
Maria Granada, Emily Cook, Gavin Sherlock, Frank Rosenzweig
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Abstract

Candida glabrata is a fungal microbe associated with multiple vertebrate microbiomes and their terrestrial environments. In humans, the species has emerged as an opportunistic pathogen that now ranks as the second-leading cause of candidiasis in Europe and North America (Beardsley et al. Med Mycol 2024, 62). People at highest risk of infection include the elderly, immunocompromised individuals and/or long-term residents of hospital and assisted-living facilities. C. glabrata is intrinsically drug-resistant, metabolically versatile and able to avoid detection by the immune system. Analyses of its 12.3 Mb genome indicate a stable pangenome Marcet-Houben et al. (BMC Biol 2022, 20) and phylogenetic affinity with Saccharomyces cerevisiae. Recent phylogenetic analyses suggest reclassifying C. glabrata as Nakaseomyces glabratus Lakashima and Sugita (Med Mycol J 2022, 63: 119-132).

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微生物简介:光滑念珠菌--欺骗大师
光滑念珠菌是一种与多种脊椎动物微生物群及其陆地环境相关的真菌微生物。在人类中,该物种已成为一种机会性病原体,目前在欧洲和北美是念珠菌病的第二大病因(Beardsley et al. Med Mycol 2024, 62)。感染风险最高的人群包括老年人、免疫力低下者和/或长期居住在医院和辅助生活设施中的人。草履蛆具有固有的耐药性、多变的新陈代谢能力并能避免被免疫系统检测到。对其 12.3 Mb 基因组的分析表明,它具有稳定的泛基因组 Marcet-Houben 等人(BMC Biol 2022, 20),与酿酒酵母具有系统发育上的亲缘关系。最近的系统发育分析表明,应将 C. glabrata 重新归类为 Nakaseomyces glabratus Lakashima and Sugita(Med Mycol J 2022, 63: 119-132)。
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来源期刊
Microbiology-Sgm
Microbiology-Sgm 生物-微生物学
CiteScore
4.60
自引率
7.10%
发文量
132
审稿时长
3.0 months
期刊介绍: We publish high-quality original research on bacteria, fungi, protists, archaea, algae, parasites and other microscopic life forms. Topics include but are not limited to: Antimicrobials and antimicrobial resistance Bacteriology and parasitology Biochemistry and biophysics Biofilms and biological systems Biotechnology and bioremediation Cell biology and signalling Chemical biology Cross-disciplinary work Ecology and environmental microbiology Food microbiology Genetics Host–microbe interactions Microbial methods and techniques Microscopy and imaging Omics, including genomics, proteomics and metabolomics Physiology and metabolism Systems biology and synthetic biology The microbiome.
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