Arthur R. Kurzbuch , Ben Cooper , John Kitchen , Andrea McLaren , Volker Tronnier , Jonathan R. Ellenbogen , on behalf of the NorCESS Team
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引用次数: 0
Abstract
Background
Complete resection is essential for achieving seizure freedom in children with drug-resistant epilepsy due to focal cortical dysplasia (FCD). However, identifying altered structures intraoperatively can be challenging, potentially leading to reoperations. This study assessed the impact of intraoperative MRI (iMRI).
Methods
We conducted a single-center retrospective study at Alder Children’s Hospital from 2013 to 2022. The study included all children diagnosed with FCD, analyzing demographics, iMRI use, the rate of continued iMRI-guided surgery and reoperations, histology, and seizure outcomes at 1-year follow-up.
Results
Thirty-two pediatric patients (median age: 10 years, 21 males and 11 females) underwent surgery for FCD. Of them 8 (25 %) had FCD Type I, 19 (59.4 %) had FCD Type II, and 1 patient (3.1 %) had FCD Type III. iMRI was used in 27 patients (84.4 %), and 17 (63 %) of these patients required further iMRI-guided surgery. Four patients underwent reoperation in a separate session. At 1-year follow-up, seizure outcomes in the iMRI group were Engel I in 15 patients (71.4 %), Engel II in 4 (19 %), and Engel III and IV in 1 patient (4.8 %) each. Five patients (15.6 %) had superficially localized lesions and underwent surgery without iMRI. None of them required reoperation, and four (80 %) were seizure-free at 1 year. Seven patients were lost to follow-up.
Conclusion
iMRI plays a significant role in identifying residual epileptogenic tissue in surgery for FCD, influencing surgical decisions and leading to additional iMRI-guided resections. Most patients with iMRI-guided surgery achieved favorable seizure outcomes (Engel I) at 1 year of follow-up. Long-term follow-up is needed to validate these findings and to confirm sustained seizure control.
期刊介绍：
This International journal, Journal of Clinical Neuroscience, publishes articles on clinical neurosurgery and neurology and the related neurosciences such as neuro-pathology, neuro-radiology, neuro-ophthalmology and neuro-physiology.
The journal has a broad International perspective, and emphasises the advances occurring in Asia, the Pacific Rim region, Europe and North America. The Journal acts as a focus for publication of major clinical and laboratory research, as well as publishing solicited manuscripts on specific subjects from experts, case reports and other information of interest to clinicians working in the clinical neurosciences.
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