Report on living liver donor risk and outcomes: Single center experience

Q4 Medicine Transplantation Reports Pub Date : 2024-11-22 DOI:10.1016/j.tpr.2024.100166
Jamilya Saparbay , Abylaikhan Sharmenov , Chokhan Aytbayev , Assylmurat Zhumukov , Bekkhozha Yeskendirov , Zhanat Spatayev , Asan Zhexembayev
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Abstract

Introduction Donor hepatectomy is considered as a major surgical procedure and can lead to severe complications. Since 2012, 64 deceased donor liver transplantation (DDLT) and 420 living donor liver transplantation were performed in Kazakhstan. Efforts to increase deceased liver donation have shown no success. In this study, we analyzed major and minor complications among living liver donor after left and right liver lobe donation, performed in our center. Patients and methods This retrospective study was conducted in compliance with the principles of the Declaration of Helsinki. The Local Ethics Committee of NROC approved this study. All data regarding living liver donors, who underwent donor hepatectomy between 2016 and 2023 were retrieved from electronic records. Results The mean age of living donors was 32 years (range 18–61).Male/female ratio was 51(70.8 %)/21(29.2). 4 left liver grafts;2 left lateral grafts and 66 right liver grafts. Bile leak occurred in 9 cases (12.5 %), 2 cases of bile leakage in living donors required surgery (Clavien grade III). Bleeding totally occurred in 3 living donors (4.2 %), in 2 cases it required surgery. PHLF occurred in 15(20.8 %) cases after right liver lobe donation. No living liver donor death was encountered in our study. Conclusions Our experience in living donor hepatectomy was not fully safe procedure. However, complication occurrence was comparable with other reports from transplant centers.
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活体肝脏捐献者的风险和结果报告:单中心经验
导言 供体肝切除术被认为是一项重大外科手术,可能导致严重的并发症。自2012年以来,哈萨克斯坦共进行了64例死亡供体肝移植(DDLT)和420例活体肝移植。增加已故肝脏捐献的努力尚未取得成功。在本研究中,我们分析了在本中心进行的左右肝叶捐献后活体肝脏捐献者的主要和次要并发症。患者和方法 本项回顾性研究符合《赫尔辛基宣言》的原则。NROC地方伦理委员会批准了这项研究。从电子记录中检索了2016年至2023年期间接受肝切除术的活体肝脏捐献者的所有数据。结果 活体肝脏捐献者的平均年龄为 32 岁(18-61 岁不等),男女比例为 51(70.8%)/21(29.2)。左肝移植 4 例;左侧移植 2 例;右肝移植 66 例。9例(12.5%)发生胆漏,2例活体捐献者胆漏需要手术(Clavien III级)。3例(4.2%)活体捐献者出现完全出血,其中2例需要手术治疗。有 15 例(20.8%)活体肝脏捐献者在捐献右肝叶后出现 PHLF。在我们的研究中,没有活体肝脏捐献者死亡。结论 我们的活体肝脏切除术并非完全安全。不过,并发症的发生率与其他移植中心的报告相当。
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来源期刊
Transplantation Reports
Transplantation Reports Medicine-Transplantation
CiteScore
0.60
自引率
0.00%
发文量
24
审稿时长
101 days
期刊介绍: To provide to national and regional audiences experiences unique to them or confirming of broader concepts originating in large controlled trials. All aspects of organ, tissue and cell transplantation clinically and experimentally. Transplantation Reports will provide in-depth representation of emerging preclinical, impactful and clinical experiences. -Original basic or clinical science articles that represent initial limited experiences as preliminary reports. -Clinical trials of therapies previously well documented in large trials but now tested in limited, special, ethnic or clinically unique patient populations. -Case studies that confirm prior reports but have occurred in patients displaying unique clinical characteristics such as ethnicities or rarely associated co-morbidities. Transplantation Reports offers these benefits: -Fast and fair peer review -Rapid, article-based publication -Unrivalled visibility and exposure for your research -Immediate, free and permanent access to your paper on Science Direct -Immediately citable using the article DOI
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