Exploring the association between BDNF related signaling pathways and depression: A literature review

IF 3.5 3区医学 Q2 NEUROSCIENCES Brain Research Bulletin Pub Date : 2024-11-26 DOI:10.1016/j.brainresbull.2024.111143

Yuchen Fan , Xinchi Luan , Xuezhe Wang , Hongchi Li , Hongjiao Zhao , Sheng Li , Xiaoxuan Li , Zhenkang Qiu

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Abstract

Depression is a debilitating mental disease that inflicts significant harm upon individuals and society, yet effective treatment options remain elusive. At present, the pathogenesis of multiple depression is not fully clear, but its occurrence can be related to biological or environmental pathways, among which Brain-derived neurotrophic factor (BDNF) can unequivocally act on two downstream receptors, tyrosine kinase receptor (TrkB) and the p75 neurotrophin receptor (p75NTR), then affect the related signal pathways, affecting the occurrence and development of depression. Accumulating studies have revealed that BDNF-related pathways are critical in the pathophysiology of depression, and their interaction can further influence the efficacy of depression treatment. In this review, we mainly summarized the signaling pathways associated with BDNF and classified them according to different receptors and related molecules, providing promising insights and future directions in the treatment of depression.

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探索 BDNF 相关信号通路与抑郁症之间的联系：文献综述

抑郁症是一种使人衰弱的精神疾病，对个人和社会造成了巨大的伤害，但有效的治疗方案却仍然难以找到。目前，多发性抑郁症的发病机制尚不完全清楚，但其发生可能与生物或环境通路有关，其中脑源性神经营养因子（BDNF）可明确作用于酪氨酸激酶受体（TrkB）和p75神经营养素受体（p75NTR）两种下游受体，进而影响相关信号通路，影响抑郁症的发生和发展。越来越多的研究发现，BDNF相关通路在抑郁症的病理生理学中起着关键作用，它们之间的相互作用会进一步影响抑郁症的治疗效果。在这篇综述中，我们主要总结了与BDNF相关的信号通路，并根据不同的受体和相关分子对其进行了分类，为抑郁症的治疗提供了有前景的见解和未来的研究方向。

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来源期刊

Brain Research Bulletin 医学-神经科学

CiteScore

6.90

自引率

2.60%

发文量

253

审稿时长

67 days

期刊介绍： The Brain Research Bulletin (BRB) aims to publish novel work that advances our knowledge of molecular and cellular mechanisms that underlie neural network properties associated with behavior, cognition and other brain functions during neurodevelopment and in the adult. Although clinical research is out of the Journal''s scope, the BRB also aims to publish translation research that provides insight into biological mechanisms and processes associated with neurodegeneration mechanisms, neurological diseases and neuropsychiatric disorders. The Journal is especially interested in research using novel methodologies, such as optogenetics, multielectrode array recordings and life imaging in wild-type and genetically-modified animal models, with the goal to advance our understanding of how neurons, glia and networks function in vivo.