Zi Yang, Ji Luo, Wenbo Zhang, Jieni Lei, Chaoshui Liu, Yaqian Li
{"title":"Rhodium(III)-catalyzed direct C-H activation of 2-aryl-3<i>H</i>-indoles: a strategy for 4-heteroaryl pyrazole synthesis.","authors":"Zi Yang, Ji Luo, Wenbo Zhang, Jieni Lei, Chaoshui Liu, Yaqian Li","doi":"10.1039/d4ob01655f","DOIUrl":null,"url":null,"abstract":"<p><p>A novel protocol for synthesizing 4-heteroaryl pyrazoles from readily available 2-aryl-3<i>H</i>-indoles and diazopyrazolones through the rhodium(III)-catalyzed C-H bond activation has been achieved. This redox-neutral strategy features powerful reactivity, tolerates various functional groups, and proceeds with moderate yields under mild reaction conditions.</p>","PeriodicalId":96,"journal":{"name":"Organic & Biomolecular Chemistry","volume":" ","pages":""},"PeriodicalIF":2.9000,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Organic & Biomolecular Chemistry","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1039/d4ob01655f","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}
引用次数: 0
Abstract
A novel protocol for synthesizing 4-heteroaryl pyrazoles from readily available 2-aryl-3H-indoles and diazopyrazolones through the rhodium(III)-catalyzed C-H bond activation has been achieved. This redox-neutral strategy features powerful reactivity, tolerates various functional groups, and proceeds with moderate yields under mild reaction conditions.