Local Stress in Cylindrically Curved Lipid Membrane: Insights into Local Versus Global Lateral Fluidity Models.

IF 4.8 2区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Biomolecules Pub Date : 2024-11-19 DOI:10.3390/biom14111471
Konstantin V Pinigin
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Abstract

Lipid membranes, which are fundamental to cellular function, undergo various mechanical deformations. Accurate modeling of these processes necessitates a thorough understanding of membrane elasticity. The lateral shear modulus, a critical parameter describing membrane resistance to lateral stresses, remains elusive due to the membrane's fluid nature. Two contrasting hypotheses, local fluidity and global fluidity, have been proposed. While the former suggests a zero local lateral shear modulus anywhere within lipid monolayers, the latter posits that only the integral of this modulus over the monolayer thickness vanishes. These differing models lead to distinct estimations of other elastic moduli and affect the modeling of biological processes, such as membrane fusion/fission and membrane-mediated interactions. Notably, they predict distinct local stress distributions in cylindrically curved membranes. The local fluidity model proposes isotropic local lateral stress, whereas the global fluidity model predicts anisotropy due to anisotropic local lateral stretching of lipid monolayers. Using molecular dynamics simulations, this study directly investigates these models by analyzing local stress in a cylindrically curved membrane. The results conclusively demonstrate the existence of static local lateral shear stress and anisotropy in local lateral stress within the monolayers of the cylindrical membrane, strongly supporting the global fluidity model. These findings have significant implications for the calculation of surface elastic moduli and offer novel insights into the fundamental principles governing lipid membrane elasticity.

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圆柱形弯曲脂质膜中的局部应力:局部与全局侧向流动性模型的启示。
脂质膜是细胞功能的基础,会发生各种机械变形。要对这些过程进行精确建模,就必须彻底了解膜的弹性。横向剪切模量是描述膜抗横向应力的关键参数,但由于膜的流体性质,这一参数仍然难以捉摸。人们提出了两种截然不同的假设,即局部流动性和整体流动性。前者认为脂质单层内任何地方的局部横向剪切模量为零,后者则认为只有该模量在单层厚度上的积分才会消失。这些不同的模型导致对其他弹性模量的不同估计,并影响生物过程的建模,如膜融合/裂变和膜介导的相互作用。值得注意的是,它们预测了圆柱形弯曲膜中不同的局部应力分布。局部流动性模型提出了各向同性的局部横向应力,而全局流动性模型则预测了由于脂质单层各向异性的局部横向拉伸而产生的各向异性。本研究利用分子动力学模拟,通过分析圆柱形弯曲膜中的局部应力,直接研究了这些模型。结果确证了圆柱膜单层内存在静态局部横向剪切应力和各向异性局部横向应力,有力地支持了全局流动性模型。这些发现对表面弹性模量的计算具有重要意义,并为了解脂质膜弹性的基本原理提供了新的视角。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Biomolecules
Biomolecules Biochemistry, Genetics and Molecular Biology-Molecular Biology
CiteScore
9.40
自引率
3.60%
发文量
1640
审稿时长
18.28 days
期刊介绍: Biomolecules (ISSN 2218-273X) is an international, peer-reviewed open access journal focusing on biogenic substances and their biological functions, structures, interactions with other molecules, and their microenvironment as well as biological systems. Biomolecules publishes reviews, regular research papers and short communications.  Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced.
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