Efficacy of Minocycline in Depression: A Systematic Review and Meta-analysis.

IF 0.8 4区医学 Q4 CLINICAL NEUROLOGY Clinical Neuropharmacology Pub Date : 2024-11-25 DOI:10.1097/WNF.0000000000000618

Hua Huang, Zhuan Zou, Bin Chen

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Abstract

Objectives: Traditional antidepressant therapy is associated with an inadequate response and a low remission rate. Our aim was to synthesize published randomized controlled trials on the potential effects of minocycline in patients with depression.

Methods: PubMed, Web of Science, Embase, and Cochrane Library databases were searched for studies published. Randomized controlled trials published in English that evaluated the efficacy of minocycline in patients with depression were selected for inclusion. Changes from baseline in the Hamilton Depression Rating Scale (HDRS) or Montgomery-Åsberg Depression Rating Scale (MADRS) were pooled to determine the antidepressant effect of minocycline compared with placebo. The quality of the included studies was assessed using the Cochrane risk-of-bias tool.

Results: Eight trials with 567 participants were eligible and included in the analysis. The meta-analysis did not reveal a statistically significant effect of minocycline on depression based on HDRS or MADRS scores.

Conclusions: According to the HDRS and MADRS scores, minocycline did not demonstrate effectiveness in reducing depressive symptoms.

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米诺环素对抑郁症的疗效：系统回顾与元分析》。

目的：传统的抗抑郁治疗反应不充分，缓解率低。我们的目的是综合已发表的关于米诺环素对抑郁症患者潜在疗效的随机对照试验：方法：在 PubMed、Web of Science、Embase 和 Cochrane Library 数据库中搜索已发表的研究。筛选出评估米诺环素对抑郁症患者疗效的英文版随机对照试验。汇总汉密尔顿抑郁评定量表（HDRS）或蒙哥马利-阿斯伯格抑郁评定量表（MADRS）与基线相比的变化，以确定米诺环素与安慰剂相比的抗抑郁效果。采用 Cochrane 偏倚风险工具对纳入研究的质量进行了评估：共有 8 项试验、567 名参与者符合条件并被纳入分析。根据 HDRS 或 MADRS 评分，荟萃分析并未发现米诺环素对抑郁症有统计学意义的影响：结论：根据 HDRS 和 MADRS 评分，米诺环素在减轻抑郁症状方面没有显示出效果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Neuropharmacology 医学-临床神经学

CiteScore

1.20

自引率

10.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Clinical Neuropharmacology is a peer-reviewed journal devoted to the pharmacology of the nervous system in its broadest sense. Coverage ranges from such basic aspects as mechanisms of action, structure-activity relationships, and drug metabolism and pharmacokinetics, to practical clinical problems such as drug interactions, drug toxicity, and therapy for specific syndromes and symptoms. The journal publishes original articles and brief reports, invited and submitted reviews, and letters to the editor. A regular feature is the Patient Management Series: in-depth case presentations with clinical questions and answers.