Stress appraisal is associated with sympathetic neural reactivity to mental stress in humans.

IF 3.3 3区 医学 Q1 PHYSIOLOGY Journal of applied physiology Pub Date : 2025-01-01 Epub Date: 2024-11-27 DOI:10.1152/japplphysiol.00678.2024
Jeremy A Bigalke, Neha A John-Henderson, Jason R Carter
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Abstract

Muscle sympathetic nerve activity (MSNA) responsiveness to mental stress is highly variable between individuals. Although stress perception has been posited as a contributor to the MSNA variability during mental stress, prior studies have been inconclusive. Furthermore, the importance of stress appraisal and coping on MSNA reactivity to mental stress has not been investigated. We hypothesize that appraisal of mental stress as a threat (i.e., perceived demands of stress exceed coping resources) versus a challenge (i.e., perceived coping resources sufficient for demands of stress) would be associated with greater MSNA reactivity. Twenty healthy adults (11 males, 9 females, 21 ± 3 yr, 23 ± 3 kg/m2) participated. Beat-by-beat blood pressure (finger plethysmography), heart rate (electrocardiography), and MSNA (microneurography) were recorded during a 10-min quiet rest followed by the Trier Social Stress Test (TSST). After each phase of the TSST (i.e., speech prep, speech, and mental arithmetic), participants reported threat versus challenge appraisal. Endorsement of a threat appraisal was positively associated with changes in MSNA burst frequency (r = 0.548, P = 0.018), burst incidence (r = 0.599, P = 0.009), and total MSNA (r = 0.697, P = 0.037) during the speech stress period. Moreover, increases in threat appraisal across tasks was associated with elevated MSNA burst frequency (r = 0.531, P = 0.023), incidence (r = 0.512, P = 0.030), and total MSNA (r = 0.727, P = 0.027) responsiveness. These findings support an association between stress appraisal processes and postganglionic sympathetic neural reactivity to psychosocial stress and may partially explain interindividual variability in MSNA responses to mental stress.NEW & NOTEWORTHY The present study investigated the association between stress appraisal and muscle sympathetic nerve activity (MSNA) reactivity to the Trier Social Stress Test. Appraisal of the stress task as a threat (i.e., perceived inability to cope with the demands of the task) was associated with exaggerated MSNA reactivity to mental stress in humans. Threat appraisal is associated with exaggerated sympathetic reactivity to stress, potentially underlying the commonly observed interindividual variability in MSNA responsiveness to mental stress.

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压力评价与人类交感神经对精神压力的反应有关。
肌肉交感神经活动(MSNA)对精神压力的反应能力因人而异。虽然压力感知被认为是导致精神压力时 MSNA 变异的一个因素,但之前的研究并没有得出结论。此外,压力评估和应对对 MSNA 对精神压力反应性的重要性也尚未得到研究。我们假设,将精神压力评价为威胁(即认为压力的需求超过了应对资源)与挑战(即认为应对资源足以应对压力的需求)将与更大的 MSNA 反应性相关。20 名健康成年人(11 名男性,9 名女性,21±3 岁,23±3 公斤/平方米)参加了此次研究。在安静休息 10 分钟后进行特里尔社交压力测试(TSST)时,记录逐次跳动的血压(指压计)、心率(心电图)和 MSNA(微神经电图)。在 TSST 的每个阶段(即演讲准备、演讲、心算)之后,参与者报告威胁与挑战评估。威胁评价的认可与言语压力期间 MSNA 爆发频率(r=0.548,p=0.018)、爆发发生率(r=0.599,p=0.009)和 MSNA 总量(r=0.697,p=0.037)的变化呈正相关。此外,不同任务中威胁评价的增加与 MSNA 突发性频率(r=0.531,p=0.023)、发生率(r=0.512,p=0.030)和 MSNA 总量(r=0.727,p=0.027)反应性的升高有关。这些发现支持压力评估过程与节后交感神经对社会心理压力的反应之间存在关联,并可部分解释 MSNA 对精神压力反应的个体差异。
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来源期刊
CiteScore
6.00
自引率
9.10%
发文量
296
审稿时长
2-4 weeks
期刊介绍: The Journal of Applied Physiology publishes the highest quality original research and reviews that examine novel adaptive and integrative physiological mechanisms in humans and animals that advance the field. The journal encourages the submission of manuscripts that examine the acute and adaptive responses of various organs, tissues, cells and/or molecular pathways to environmental, physiological and/or pathophysiological stressors. As an applied physiology journal, topics of interest are not limited to a particular organ system. The journal, therefore, considers a wide array of integrative and translational research topics examining the mechanisms involved in disease processes and mitigation strategies, as well as the promotion of health and well-being throughout the lifespan. Priority is given to manuscripts that provide mechanistic insight deemed to exert an impact on the field.
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