Differential contributions of the C1 ERP and broadband high-frequency activity to visual processing.

Abstract

The high-frequency activity (HFA; 80-150 Hz) in human intracranial recordings shows a differential modulation to different degrees in contrast when stimuli are behaviorally relevant, indicating a feedforward process. However, the HFA is also significantly dominated by superficial layers and exhibits a peak before 200 ms, suggesting that it is more likely a feedback signal. Magnetoencephalographic (MEG) recordings are suited to reveal an HFA modulation similar to its modulation in intracranial recordings. This allows for noninvasive, direct comparison of HFA with the C1, an established measure for feedforward input to V1, to test whether HFA represents feedforward or rather feedback. In simultaneous recordings, we used the EEG-C1 event-related potential (ERP) component and MEG-HFA to define feedforward processing in visual cortices. C1 latency preceded the HFA peak modulation, which had a more sustained response. Furthermore, modulation parameters like onset, peak time, and peak amplitude were uncorrelated. Most importantly, the C1 but not HFA distinguished small task-irrelevant contrast differences in visual stimulation. These results highlight the differential roles for the C1 and HFA in visual processing with the C1 measuring feedforward discrimination ability and HFA indexing feedforward and feedback processing.NEW & NOTEWORTHY Whether the broadband high-frequency activity (HFA) represents exclusively feedforward or feedback processing remains unclear. In this study, we compared the response characteristics of the HFA-magnetoencephalographic (MEG) and the C1-EEG component to systematic contrast modulations of task-irrelevant visual stimulation. Our findings reveal that the more sustained HFA follows the C1 component and, unlike the C1, is not modulated by task-irrelevant contrast differences. This timing of the HFA modulation suggests that HFA encompasses both feedforward and feedback processing.