Sodium Alginate Microneedles Loaded with Vancomycin for Skin Infections.

IF 5 3区医学 Q1 ENGINEERING, BIOMEDICAL Journal of Functional Biomaterials Pub Date : 2024-10-25 DOI:10.3390/jfb15110316

Juhaina M Abu Ershaid, Han Zhang, May Tayyem, Akmal H Sabri, Ryan F Donnelly, Lalitkumar K Vora

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Abstract

Background: Skin and soft tissue infections (SSTIs) present significant treatment challenges. These infections often require systemic antibiotics such as vancomycin, which poses a risk for increased bacterial resistance. Topical treatments are hindered by the barrier function of the skin, and microneedles (MNs) offer a promising solution, increasing patient compliance and negating the need for traditional needles.

Methods: This study focused on the use of sodium alginate MNs for vancomycin delivery directly to the site of infection via a cost-effective micromolding technique. Dissolving polymeric MNs made of sodium alginate and loaded with vancomycin were fabricated and evaluated in terms of their physical properties, delivery ability, and antimicrobial activity.

Results: The MNs achieved a 378 μm depth of insertion into ex vivo skin and a 5.0 ± 0 mm zone of inhibition in agar disc diffusion assays. Furthermore, in ex vivo Franz cell experiments, the MNs delivered 34.46 ± 11.31 μg of vancomycin with around 35% efficiency, with 9.88 ± 0.57 μg deposited in the skin after 24 h.

Conclusions: These findings suggest that sodium alginate MNs are a viable platform for antimicrobial agent delivery in SSTIs. Future in vivo studies are essential to confirm the safety and effectiveness of this innovative method for clinical use.

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装载万古霉素的海藻酸钠微针治疗皮肤感染

背景：皮肤和软组织感染（SSTI）给治疗带来了巨大挑战。这些感染通常需要使用万古霉素等全身性抗生素，这有可能增加细菌耐药性。局部治疗因皮肤的屏障功能而受到阻碍，微针（MNs）提供了一种很有前景的解决方案，可提高患者的依从性，且无需使用传统针头：本研究的重点是使用海藻酸钠微针，通过经济有效的微成型技术将万古霉素直接输送到感染部位。研究人员制作了由海藻酸钠制成的溶解聚合物 MNs，并对其物理性质、输送能力和抗菌活性进行了评估：结果：MNs 在体外皮肤中的插入深度为 378 μm，在琼脂盘扩散实验中的抑制区为 5.0 ± 0 mm。此外，在体外弗兰茨细胞实验中，MNs 释放了 34.46 ± 11.31 μg 万古霉素，有效率约为 35%，24 小时后有 9.88 ± 0.57 μg 沉积在皮肤中：这些研究结果表明，海藻酸钠 MNs 是在 SSTI 中输送抗菌剂的可行平台。未来的体内研究对于确认这种创新方法在临床应用中的安全性和有效性至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Functional Biomaterials Engineering-Biomedical Engineering

CiteScore

4.60

自引率

4.20%

发文量

226

审稿时长

11 weeks

期刊介绍： Journal of Functional Biomaterials (JFB, ISSN 2079-4983) is an international and interdisciplinary scientific journal that publishes regular research papers (articles), reviews and short communications about applications of materials for biomedical use. JFB covers subjects from chemistry, pharmacy, biology, physics over to engineering. The journal focuses on the preparation, performance and use of functional biomaterials in biomedical devices and their behaviour in physiological environments. Our aim is to encourage scientists to publish their results in as much detail as possible. Therefore, there is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. Several topical special issues will be published. Scope: adhesion, adsorption, biocompatibility, biohybrid materials, bio-inert materials, biomaterials, biomedical devices, biomimetic materials, bone repair, cardiovascular devices, ceramics, composite materials, dental implants, dental materials, drug delivery systems, functional biopolymers, glasses, hyper branched polymers, molecularly imprinted polymers (MIPs), nanomedicine, nanoparticles, nanotechnology, natural materials, self-assembly smart materials, stimuli responsive materials, surface modification, tissue devices, tissue engineering, tissue-derived materials, urological devices.