Initial Exploration of the In Vitro Activation of GLP-1 and GIP Receptors and Pancreatic Islet Cell Protection by Salmon-Derived Bioactive Peptides.

IF 5.4 2区医学 Q1 CHEMISTRY, MEDICINAL Marine Drugs Pub Date : 2024-10-30 DOI:10.3390/md22110490

Crawford Currie, Christian Bjerknes, Bomi Framroze

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Abstract

This study examines the in vitro effects of a soluble protein hydrolysate (SPH) derived from Atlantic salmon (Salmo salar) on incretin receptor activity and pancreatic islet cell protection to explore the mechanisms underlying SPH's observed benefits on weight loss and metabolic health in overweight individuals. SPH demonstrated a dose-dependent enhancement of glucagon-like peptide-1 (GLP-1) and gastric inhibitory polypeptide (GIP) receptor activity, with significant increases of 2.4-fold (p < 0.05) and 2.6-fold (p < 0.01) at 10 mg/mL, respectively, compared to the control. Pancreatic islet cell assays showed a substantial proliferation effect, with up to a 57% increase at 50 µL/well, indicating potential protective properties against inflammation-induced cell loss. Notably, the smallest SPH peptide fraction (<1000 Da) exhibited GLP-1 agonist activity comparable to semaglutide, a widely used therapeutic agent, underscoring SPH's potential efficacy in modulating metabolic pathways. These results suggest that SPH not only enhances key incretin signaling but also promotes islet cell health, positioning it as a promising dietary intervention to improve age-related metabolic health, including the weight gain and underlying adverse metabolic changes frequently encountered through the menopause.

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对鲑鱼提取的生物活性肽体外激活 GLP-1 和 GIP 受体以及保护胰岛细胞的初步探索。

本研究考察了大西洋鲑鱼（Salmo salar）提取的可溶性蛋白水解物（SPH）对增量素受体活性和胰岛细胞保护的体外效应，以探索 SPH 对超重者减肥和新陈代谢健康有益的机制。与对照组相比，SPH 对胰高血糖素样肽-1（GLP-1）和胃抑制多肽（GIP）受体活性的增强具有剂量依赖性，10 毫克/毫升时分别显著增加 2.4 倍（p < 0.05）和 2.6 倍（p < 0.01）。胰腺胰岛细胞检测显示了显著的增殖效果，50 µL/孔时可增加57%，这表明了对炎症引起的细胞损失的潜在保护特性。值得注意的是，最小的 SPH 肽组分（50 微升/孔）对胰岛细胞有显著的增殖作用。

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来源期刊

Marine Drugs 医学-医药化学

CiteScore

9.60

自引率

14.80%

发文量

671

审稿时长

1 months

期刊介绍： Marine Drugs (ISSN 1660-3397) publishes reviews, regular research papers and short notes on the research, development and production of drugs from the sea. Our aim is to encourage scientists to publish their experimental and theoretical research in as much detail as possible, particularly synthetic procedures and characterization information for bioactive compounds. There is no restriction on the length of the experimental section.