Metagenomic next-generation sequencing may assist diagnosis of osteomyelitis caused by Mycobacterium houstonense: A case report.

IF 2 Q2 ORTHOPEDICS World Journal of Orthopedics Pub Date : 2024-11-18 DOI:10.5312/wjo.v15.i11.1095

Hong-Yin Lin, Quan-Hui Tan

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Abstract

Background: Mycobacterium houstonense (M. houstonense) belongs to the nontuberculous mycobacterium group. Infection caused by M. houstonense is prone to recurrence.

Case summary: We present a patient who was diagnosed with osteomyelitis caused by M. houstonense and treated with a combination of cefoxitin, and amikacin combined with linezolid.

Conclusion: The emergence of metagenomic next-generation sequencing (NGS) has brought new hope for the diagnosis and treatment of listeria meningitis. NGS can analyze a large number of nucleic acid sequences in a short time and quickly determine the pathogen species in the sample. Compared with traditional cerebrospinal fluid culture, NGS can greatly shorten the diagnosis time and provide strong support for the timely treatment of patients. Regarding treatment, NGS can also play an important role. Rapid and accurate diagnosis can enable patients to start targeted treatment as soon as possible and improve the treatment effect. At the same time, by monitoring the changes in pathogen resistance, the treatment plan can be adjusted in time to avoid treatment failure.

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元基因组下一代测序可协助诊断由休斯顿分枝杆菌引起的骨髓炎：病例报告。

背景：休斯顿分枝杆菌（M. houstonense）属于非结核分枝杆菌。病例摘要：我们介绍了一名被诊断为由侯斯顿氏分枝杆菌引起的骨髓炎患者，该患者接受了头孢西丁、阿米卡星联合利奈唑胺的治疗：结论：元基因组下一代测序（NGS）的出现为李斯特菌脑膜炎的诊断和治疗带来了新的希望。NGS 可在短时间内分析大量核酸序列，快速确定样本中的病原体种类。与传统的脑脊液培养相比，NGS 可以大大缩短诊断时间，为患者的及时治疗提供有力支持。在治疗方面，NGS 也能发挥重要作用。快速准确的诊断可以使患者尽快开始针对性治疗，提高治疗效果。同时，通过监测病原体耐药性的变化，可以及时调整治疗方案，避免治疗失败。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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