Evaluating neuronal damage biomarkers at birth for predicting neurodevelopmental risks in foetal growth restriction.

IF 2.4 4区医学 Q1 PEDIATRICS Acta Paediatrica Pub Date : 2024-11-27 DOI:10.1111/apa.17521

Mª José Benítez-Marín, Marta Blasco-Alonso, Fernando de Rodríguez de Fonseca, Jesús S Jiménez, Patricia Rivera, Ernesto González-Mesa

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Abstract

Aim: This study was based on the need to predict neurodevelopmental outcomes of children with foetal growth restriction. The aim was to systematically review the correlation between biomarkers of neural injury in children with foetal growth restriction and their neurodevelopment.

Method: Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, the review included studies on growth-restricted foetuses that measured biomarkers of postpartum brain injury and assessed neurodevelopment in childhood. Studies published between 1 January 2014 and 31 March 2024 were identified through PubMed and Embase, with the study protocol registered in PROSPERO (CRD42024520254).

Results: Only five met the inclusion criteria. Results showed that urinary S100B levels were significantly elevated in foetal growth restriction, negatively correlating with neurological development at 7 days of life. Neuron-specific enolase negatively correlated with cognitive, motor and socio-emotional development. Urinary nerve growth factor levels were significantly lower in neonates with foetal growth restriction, correlating with poor neurodevelopment. No alterations in BDNF levels were observed. Tau protein levels were lower in children with foetal growth restriction and adverse outcomes.

Conclusion: The study emphasised the need for further research on biomarkers and predictive models of neurodevelopment in children with foetal growth restriction.

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评估出生时神经元损伤生物标志物，以预测胎儿生长受限的神经发育风险。

目的：本研究基于预测胎儿生长受限儿童神经发育结果的需要。目的是系统回顾胎儿生长受限儿童神经损伤生物标志物与其神经发育之间的相关性：根据《系统综述和荟萃分析首选报告项目》指南，该综述纳入了有关生长受限胎儿的研究，这些研究测量了产后脑损伤的生物标志物，并评估了儿童时期的神经发育情况。通过PubMed和Embase查找了2014年1月1日至2024年3月31日期间发表的研究，并在PROSPERO（CRD42024520254）中登记了研究方案：结果：只有五项符合纳入标准。结果表明，胎儿生长受限时尿S100B水平显著升高，与出生7天后的神经系统发育呈负相关。神经元特异性烯醇化酶与认知、运动和社会情感发育呈负相关。胎儿生长受限的新生儿尿液中神经生长因子水平明显较低，与神经发育不良有关。未观察到 BDNF 水平的变化。胎儿生长受限和不良预后患儿的 Tau 蛋白水平较低：该研究强调了进一步研究胎儿生长受限儿童神经发育的生物标志物和预测模型的必要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta Paediatrica 医学-小儿科

CiteScore

6.50

自引率

5.30%

发文量

384

审稿时长

2-4 weeks

期刊介绍： Acta Paediatrica is a peer-reviewed monthly journal at the forefront of international pediatric research. It covers both clinical and experimental research in all areas of pediatrics including: neonatal medicine developmental medicine adolescent medicine child health and environment psychosomatic pediatrics child health in developing countries