Respiratory Viral Infection Patterns in Hospitalised Children Before and After COVID-19 in Hong Kong.

IF 3.8 3区 医学 Q2 VIROLOGY Viruses-Basel Pub Date : 2024-11-17 DOI:10.3390/v16111786
Jason Chun Sang Pun, Kin Pong Tao, Stacy Lok Sze Yam, Kam Lun Hon, Paul Kay Sheung Chan, Albert Martin Li, Renee Wan Yi Chan
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Abstract

The study highlights the significant changes in respiratory virus epidemiology following the lifting of COVID-19 restrictions.

Method: In this single-centre retrospective study, the virological readouts of adenovirus (AdV), influenza virus A (IAV), influenza virus B (IBV), parainfluenza viruses (PIV) 1, 2, 3, 4, respiratory syncytial virus (RSV), and coupled enterovirus and rhinovirus (EV/RV) were extracted from the respiratory specimens of paediatric patients in Hong Kong from January 2015 to February 2024. The subjects were stratified into five age groups.

Results: The study included 18,737 and 6001 respiratory specimens in the pre-COVID-19 and post-COVID-19 mask mandate period, respectively. The mean age of hospitalised patients increased from 3.49 y ± 0.03 y to 4.37 y ± 0.05 y after the COVID-19 lockdown. The rates of single-virus infection and co-infection were significantly higher in the post-COVID-19 mask mandate period. The odds ratio for AdV for all age groups (OR: 4.53, 4.03, 2.32, 2.46, 1.31) and RSV in older children from 3 years old and above (OR: 1.95, 3.38, p < 0.01) were significantly elevated after the COVID-19 outbreak.

Conclusions: Our findings suggest that public health measures to contain COVID-19 may have unintended consequences on children's natural exposure and immunity to other respiratory viruses, potentially increasing their morbidity in the post-pandemic era.

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香港住院儿童在 COVID-19 前后的呼吸道病毒感染模式。
该研究强调了 COVID-19 解除限制后呼吸道病毒流行病学的重大变化:在这项单中心回顾性研究中,研究人员从 2015 年 1 月至 2024 年 2 月期间香港儿科患者的呼吸道标本中提取了腺病毒 (AdV)、甲型流感病毒 (IAV)、乙型流感病毒 (IBV)、副流感病毒 (PIV) 1、2、3、4、呼吸道合胞病毒 (RSV) 以及肠道病毒和鼻病毒 (EV/RV) 的病毒学读数。研究对象分为五个年龄组:研究分别纳入了18737份和6001份COVID-19前和COVID-19后口罩授权期的呼吸道标本。COVID-19 封锁后,住院患者的平均年龄从 3.49 岁 ± 0.03 岁增加到 4.37 岁 ± 0.05 岁。在 COVID-19 禁用后的口罩授权期,单一病毒感染率和合并感染率均明显升高。COVID-19疫情爆发后,所有年龄组的AdV感染几率(OR:4.53、4.03、2.32、2.46、1.31)和3岁及以上大龄儿童的RSV感染几率(OR:1.95、3.38,P < 0.01)均明显升高:我们的研究结果表明,遏制 COVID-19 的公共卫生措施可能会对儿童对其他呼吸道病毒的自然暴露和免疫力产生意想不到的影响,从而有可能在疫情过后增加儿童的发病率。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Viruses-Basel
Viruses-Basel VIROLOGY-
CiteScore
7.30
自引率
12.80%
发文量
2445
审稿时长
1 months
期刊介绍: Viruses (ISSN 1999-4915) is an open access journal which provides an advanced forum for studies of viruses. It publishes reviews, regular research papers, communications, conference reports and short notes. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. We also encourage the publication of timely reviews and commentaries on topics of interest to the virology community and feature highlights from the virology literature in the ''News and Views'' section. Electronic files or software regarding the full details of the calculation and experimental procedure, if unable to be published in a normal way, can be deposited as supplementary material.
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