Use of Medications With Somnolence Adverse Effects and Somnolence Symptoms Among Older Adults in the U.S.

IF 2.2 3区医学 Q2 GERONTOLOGY Journal of Aging and Health Pub Date : 2024-11-26 DOI:10.1177/08982643241298734

Jocelyn Wilder, Diane Lauderdale, Dima M Qato

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Abstract

Objectives: Nearly half of older adults experience somnolence, but the link between medications with somnolence as an adverse effect and somnolence is unclear. This study investigated the association between polypharmacy and somnolence symptoms (excessive sleepiness or long sleep duration).

Methods: Data from the National Social Life, Health, and Aging Project (NSHAP) 2010-2011 was used to examine the concurrent use of medications with potential somnolence as an adverse effect and the prevalence of somnolence symptoms.

Results: Among the 2638 older adults (mean, 71 years), 49.0% used medications with potential somnolence adverse effects. The adjusted prevalence of somnolence symptoms was significantly higher among those using three or more medications (58%) than those not using such medications (31.2%) (difference, 20.4%; 95% CI 12.5, 28.4).

Discussion: In this cross-sectional study, medications with somnolence as a potential adverse effect were commonly used, and the findings suggest a link between polypharmacy and the increased risk of somnolence symptoms.

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美国老年人使用具有嗜睡不良反应和嗜睡症状的药物情况

目的：近一半的老年人会出现嗜睡症状，但以嗜睡为不良反应的药物与嗜睡之间的关系尚不清楚。本研究调查了多种药物治疗与嗜睡症状（过度嗜睡或睡眠时间过长）之间的关系：方法：利用 2010 至 2011 年国家社会生活、健康和老龄化项目（NSHAP）的数据，研究同时使用可能会导致嗜睡不良反应的药物与嗜睡症状的发生率：结果：在 2638 名老年人（平均 71 岁）中，49.0% 的人服用了可能会引起嗜睡不良反应的药物。经调整后，使用三种或三种以上药物者（58%）的嗜睡症状发生率明显高于未使用此类药物者（31.2%）（差异为 20.4%；95% CI 为 12.5 至 28.4）：讨论：在这一横断面研究中，将嗜睡作为潜在不良反应的药物是常用药物，研究结果表明，多药治疗与嗜睡症状风险增加之间存在联系。

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来源期刊

Journal of Aging and Health Multiple-

CiteScore

5.60

自引率

3.60%

发文量

113

期刊介绍： The Journal of Aging and Health is an interdisciplinary forum for the presentation of research findings and scholarly exchange in the area of aging and health. Manuscripts are sought that deal with social and behavioral factors related to health and aging. Disciplines represented include the behavioral and social sciences, public health, epidemiology, demography, health services research, nursing, social work, medicine, and related disciplines. Although preference is given to manuscripts presenting the findings of original research, review and methodological pieces will also be considered.