The Usefulness of Exosomes in Accelerating Healing and Preventing Complications in Behçet's Disease: A Case Report.

Abstract

Behçet's disease (BD) is a systemic auto-inflammatory vasculitis. The clinical pictures of BD involve the skin and mucosal membranes such as oral and genital ulcers, ocular lesions, cardiovascular, gastrointestinal, muscular, nervous systems, and joints. A 38-year-old woman was repeatedly suffering from oral, genital, and ocular lesions, wound dehiscence after any surgical procedure, and joint pain. She has a family history where multiple relatives were affected by BD. The patient had an abdominoplasty two years ago with delayed wound healing and keloid formation. The patient presented with an asymmetrical labia majora with multiple lumps after fat transfer, multiple vaginal cysts, and a chronic Bartholin's cyst for three years. She consulted surgeons to correct the deformity and for cyst excision, but there was a great risk of keloid formation, dehiscence, and infections. This was a challenge for her surgery. The patient was on colchicine and corticosteroids. BD affects multiple systems, most commonly the healing of the skin and the mucous membranes. This causes difficulties in deciding to undergo surgery because of the risks. The diversity of the manifestations of BD requires a spectrum of pre-surgical adjustments in inflammatory markers, medication doses, and improving general patient conditions. Furthermore, the intra-operative and post-operative use of the recent regenerative medicine methods might provide the best surgical healing outcomes in these groups of patients. This is most challenging with BD but can be achieved regardless.