{"title":"Regulating Histone Deacetylases and Carbonic Anhydrases by Metal Complexes: A Potent Strategy for Treating Cancers.","authors":"Yen Thi Nguyen, Namdoo Kim, Hyuck Jin Lee","doi":"10.24976/Discov.Med.202436190.198","DOIUrl":null,"url":null,"abstract":"<p><p>Utilizing metal complexes to inhibit histone deacetylases (HDACs) and carbonic anhydrases (CAs) highlights their therapeutic potential, particularly in anticancer strategies. The metal complexes, with their unique three-dimensional structures, fit adequately into the active sites of the enzymes, not only improving selectivity but also providing facile coordination with amino acid residues to enhance their inhibitory ability. This review emphasizes the role of metal complexes in the selective inhibition of HDACs and CAs along with details of their mechanism of action. Additionally, we summarize the inhibition ability and cytotoxicity of metal complexes targeting HDACs and CAs, as well as the therapeutic implications that can lead to the invention and development of metal complexes as potent anticancer agents.</p>","PeriodicalId":93980,"journal":{"name":"Discovery medicine","volume":"36 190","pages":"2152-2174"},"PeriodicalIF":0.0000,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Discovery medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.24976/Discov.Med.202436190.198","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Utilizing metal complexes to inhibit histone deacetylases (HDACs) and carbonic anhydrases (CAs) highlights their therapeutic potential, particularly in anticancer strategies. The metal complexes, with their unique three-dimensional structures, fit adequately into the active sites of the enzymes, not only improving selectivity but also providing facile coordination with amino acid residues to enhance their inhibitory ability. This review emphasizes the role of metal complexes in the selective inhibition of HDACs and CAs along with details of their mechanism of action. Additionally, we summarize the inhibition ability and cytotoxicity of metal complexes targeting HDACs and CAs, as well as the therapeutic implications that can lead to the invention and development of metal complexes as potent anticancer agents.
利用金属复合物抑制组蛋白去乙酰化酶（HDACs）和碳酸酐酶（CAs）凸显了它们的治疗潜力，尤其是在抗癌策略中。金属复合物具有独特的三维结构，能与酶的活性位点充分贴合，不仅能提高选择性，还能方便地与氨基酸残基配位，从而增强其抑制能力。本综述强调了金属复合物在选择性抑制 HDAC 和 CA 方面的作用，并详细介绍了它们的作用机制。此外，我们还总结了针对 HDACs 和 CAs 的金属复合物的抑制能力和细胞毒性，以及其治疗意义，这有助于发明和开发作为强效抗癌剂的金属复合物。
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